大肠埃希菌PPK极端环境下调控作用研究进展  

Progress in Researches on Regulation Mechanism of Polyphosphate Kinase in Escherichia coli in Extreme Environment

作　　者：张蕾丝 王湘雨[2] 韩朋[2] 万成松[2] 

机构地区：[1]南方医科大学第一临床医学院,临床医学八年制广东广州510515 [2]南方医科大学公共卫生与热带医学学院微生物学系,广东广州510515

出　　处：《生物技术》2014年第5期99-102,共4页Biotechnology

基　　金：广东省自然科学基金项目("大肠杆菌O157:H7 EspF蛋白诱导细胞凋亡分子机制研究";No.s2013010014393)资助

摘　　要：为了阐明大肠埃希菌多聚磷酸盐激酶在极端环境下的调控作用,该文分析了多聚磷酸盐激酶参与大肠埃希菌应对Rpo S主导的广泛压力响应、DNA损伤修复、营养缺乏、蛋白降解、生物被膜形成等不利环境的反应,论述了多聚磷酸激酶在基因转录、蛋白修饰等分子调控机制的研究现状,展望了多聚磷酸盐激酶在抗菌药物靶点筛选和生物杀虫剂候选方面的研究前景。大肠埃希菌的多聚磷酸盐激酶可能在信号转导、细菌毒力及适应氧化压力、紫外辐射、热激、高渗、酸性p H等不利环境等方面发挥重要调控作用。This paper was written to clarify the regulation of Polyphosphate kinase（ PPK） in Escherichia coli living in extreme environment. In this paper,how PPK performed in Rpo S regulating system,repair of DNA damage,protein degeneration,and the form of biofilm,was reviewed. Research on PPK at molecular level, for example regulating gene transcription and protein modification, was introduced. Finally,study of PPK in evolution,antibiotic medicine and bioinsecticide production was prospected. PPK in Escherichia coli might play an important role in signal transduction,toxin,and extreme environment such as low oxygen,nutritional deficiencies,radiation and high temperature.

关 键 词：大肠埃希菌 多聚磷酸盐激酶 极端环境 调控 

分 类 号：Q71[生物学—分子生物学]