荨麻疹患者血清IL-4,IL-17及IFN-γ水平的检测  

Detection of Interleukin-4,Interleukin-17 and IFN-γ in Serum of Patients with Urticaria

作　　者：杨义成[1] 肖海珍[1] 吴海斌[1] 孙辉[1] 付敏[1] 陈华[1] 石建萍[1] 

机构地区：[1]广州医科大学附属深圳沙井人民医院皮肤科,广东深圳518104

出　　处：《中国皮肤性病学杂志》2014年第11期1124-1126,共3页The Chinese Journal of Dermatovenereology

基　　金：深圳市宝安区科研项目(2012114)

摘　　要：目的测定白介素-4(IL-4),白介素-17(IL-17)及γ-干扰素(IFN-γ)在急、慢性荨麻疹患者血中水平,探讨其在疾病中的作用。方法对30例急性荨麻疹患者和30例慢性荨麻疹患者,用ELISA法测定血清IL-4,IL-17及IFN-γ,并与正常对照组进行比较。结果 ELISA检测血清IL-17在荨麻疹组有明显增高,尤其在慢性荨麻疹中,与对照组差异有统计学意义(P<0.05);IL-4在急性,慢性荨麻疹中有明显增高,与对照组差异有统计学意义(P<0.05);急慢性荨麻疹患者IFN-γ与对照组差异无统计学意义(P>0.05)。结论 IL-4,IL-17分别在急性,慢性荨麻疹的发病中发挥了重要作用。Objective To investigate the levels of IL-4, IL-17 and IFN-γ in serum of the patients with acute and chron- ic urticaria,and to explore their roles in the disease. Methods The serum concentrations of IL-4, IL-17 and IFN-γ were detected by ELISA in 30 patients with acute urticarial ,30 patients with chronic urticaria, and normal controls. Results Compared with normal controls,the levels of IL-17 and IL-4 in the patients with urticaria, in particular, chronic urticaria, were significantly higher （ P 〈 0.05 ）. There was no significant difference in the level of IFN-γ between urticaria group and controls （P 〉 0.05 ）. Conclusion IL-17 and IL-4 play an important role in the pathogenesis of both acute and chronic urticaria.

关 键 词：荨麻疹 白细胞介素4 白细胞介素17 干扰素(IFN-γ) 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]