Medlite C6激光联合左旋维生素C治疗黄褐斑的疗效及安全性分析  

The Efficacy and Safety of the Medlite C6 Laser Combined with Topical L-ascorbic Acid Serum for Melasma

作　　者：高睿迪 王颖[1] 廖春[1] 赵阳[1] 杨慧兰[1] 

机构地区：[1]广州军区广州总医院皮肤科,广东广州510010

出　　处：《中国皮肤性病学杂志》2014年第11期1180-1183,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的研究Medlite C6激光联合外用左旋维生素C治疗黄褐斑的临床疗效及安全性。方法对确诊黄褐斑的20名志愿者进行Medlite C6激光(每3周1次共4次)联合日常外用左旋维生素C的治疗,并在每次治疗前使用皮肤测试仪对皮肤进行红斑、黑素、皱纹及含水量的检测,同时另取20名黄褐斑患者进行外用左旋维生素C的对照治疗,检测指标相同。结果经过4次治疗,治疗组患者黑素指数、皱纹深度逐渐降低,红斑指数在后3次治疗中逐渐改善,皮肤含水量在前2次治疗后明显改善;对照组患者皱纹深度的治疗效果相对有限,余指标均逐渐改善,但改善程度较治疗组低。结论 Medlite C6激光联合外用左旋维生素C可以安全、有效、较快地改善黄褐斑患者的皮肤情况,左旋维生素C也可有效改善病情,但起效较慢。Objective To evaluate the efficacy and safety of the Medlite C6 laser combined with topical 23.8% L-ascorbic acid serum on melasma. Methods Forty patients with melasma were enrolled in this study. Twenty patients received Medlite C6 laser once every three weeks and topical 23.8% L-ascorbic acid serum on the whole face daily for a total of 12 weeks. Prior to each laser treatment ,the erythema/melanin/wrinkle/skin hydration on the face were measured with a skin evaluation instrument made by Callegari, Italy. Twenty patients received topical 23.8% L-aseorbic acid serum as the controls. Results During the course of treatment, the wrinkle depth and melanin index gradually decreased in the treatment group. The erythema index improved during the last three laser treatments, while skin hydration improved during the first two laser treatments. Except for wrinkle depth,23.8% L-aseorbie acid serum improved all other biophysical parameters ,but to a less extent compared to the treatment group. Conclusion Medlite C6 laser in combination with topical 23.8% L-ascorbic acid serum is a safe and effective regimen to rapidly improve the skin condition in melasma although topical 23.8% L-ascorbic acid serum can also slowly im!~rove the skin condition.

关 键 词：黄褐斑 MEDLITE C6激光 左旋维生素C 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]