过敏性紫癜患儿尿肾脏损伤因子-1水平的变化及意义  

The role of urinary kidney injury molecule-1 in pediatric Henoch-Schnlein purpura

作　　者：夏慧 茅幼英 周纬[1] 陈同辛[1] 

机构地区：[1]上海交通大学医学院附属上海儿童医学中心,上海200127

出　　处：《临床儿科杂志》2014年第10期918-920,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨肾脏损伤因子1(KIM-1)与过敏性紫癜(HSP)的关系。方法采用ELISA法检测48例HSP患儿,其中25例非HSP肾炎患儿(HSP组)、23例HSP肾炎患儿(HSPN组),以及20例健康对照儿童的尿KIM-1水平;并检测尿肌酐、24 h尿蛋白水平,进行分析比较。结果 HSPN组的尿KIM-1/尿肌酐比值较HSP组和对照组增高,差异有统计学意义(P均<0.05);HSP组与对照组的尿KIM-1/尿肌酐比值差异无统计学意义(P>0.05)。HSP患儿的尿KIM-1/尿肌酐比值与24h尿蛋白水平无相关性(r=0.239,P=0.590)。结论尿KIM-1与HSPN的发生有关,KIM-1表达的上调可能是HSP肾损害发生的重要机制之一。Objective To study the role of urinary kidney injury molecule-1 （KIM-1） in pediatric Henoch-Sch？nlein purpura （HSP）. Methods Urinary levels of KIM-1 were examined using ELISA in 48 children with HSP including 23 HSPN children （HSPN group） and 25 non-HSPN children （HSP group）, and 20 healthy children. The levels of urinary creatinine and 24-hour urine protein were also detected. The results were analyzed and compared among groups. Results The ratio of urinary KIM-1/creatinine （Cr） in HSPN children was signiifcantly higher than that in the other two groups （P〈0.05）. There was no signiifcant difference in the ratio of urinary KIM-1/Cr between HSP group and the control group （P〉0.05）. The ratio of urinary KIM-1/Cr had no correlation with 24-hour urine protein in all HSP children （r=0.239, P=0.590）. Conclusions Urinary KIM-1 may play a role in the pathogenesis of pediatric HSPN.

关 键 词：过敏性紫癜 肾脏损伤因子1 儿童 

分 类 号：R725.5[医药卫生—儿科]