Th17细胞在过敏性紫癜患儿外周血中的分布及意义  

Distribution of Th17 cells in peripheral blood of children with Henoch-Schnlein purpura and its clinical significance

作　　者：李燕林[1] 王永清[1] 朱迪卿[1] 周益平[1] 

机构地区：[1]常州市第一人民医院,江苏常州213000

出　　处：《临床儿科杂志》2014年第10期921-923,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨过敏性紫癜(HSP)患儿外周血单个核细胞(PBMCs)中Th17细胞比例及血清IL-17水平变化的临床意义。方法选择HSP患儿30例和正常对照儿童20例,应用流式细胞分析法检测外周血Th17细胞的比例,应用ELISA法检测血清IL-17水平,分析和比较HSP患儿和对照儿童的检测结果。结果 HSP患儿PBMCs中Th17细胞比例为(2.14±0.90)%,显著高于对照组的(0.84±0.41)%,差异有统计学意义(P<0.05);HSP患儿血清IL-17水平为(38.36±13.44)pg/ml,高于对照组的(10.59±4.17)pg/ml,差异有统计学意义(P<0.05)。结论 HSP患儿PBMC中Th17细胞比例明显增高,提示Th17细胞可能参与了HSP的发病过程。Objective To observe the percentage of Th17 cells in peripheral blood mononuclear cells （PBMCs） and the serum level of interleukin-17 （IL-17） in children with Henoch-Schonlein purpura （HSP）. Methods A total of 30 HSP children and 20 healthy children were selected. The percentage of Th17 cells in PBMCs was measured by lfow cytometry analysis and the serum level of IL-17 was measured by ELISA method. The results were compared between HSP children and healthy children. Results The percentage of Th17 cells in PBMCs in HSP and healthy children was （2.14 ± 0.90）%and （0.84 ± 0.41）%, respec-tively, and the difference was signiifcant between two groups （P〈0.05）. The serum levels of IL-17 in HSP and healthy children were （38.36 ± 13.44） pg/ml and （10.59 ± 4.17） pg/ml, respectively, and the difference was also signiifcant （P〈0.05）. Conclusions The percentage of Th17 cells in PBMCs was obviously increased in HSP children. It is suggested that Th17 cells may play a role in the pathology of HSP.

关 键 词：过敏性紫癜 TH17细胞 白介素17 

分 类 号：R725.5[医药卫生—儿科]