急性传染性淋巴细胞增多症患儿外周血共刺激分子4-1BB和淋巴细胞亚群的表达及意义  

Expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis

作　　者：付强[1] 封其华[2] 余孔贵[1] 唐临飞[1] 李爱民[1] 宋晓翔[2] 

机构地区：[1]华中科技大学同济医学院附属荆州医院儿科,湖北荆州434000 [2]苏州大学附属儿童医院肾脏免疫科,江苏苏州215003

出　　处：《临床儿科杂志》2014年第10期928-930,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨急性传染性淋巴细胞增多症(AIL)患儿外周血共刺激分子4-1BB和淋巴细胞亚群的表达及意义。方法应用流式细胞术(FCM)检测和比较15例AIL患儿、20例急性上呼吸道感染(URI)患儿以及20例健康对照儿童的外周血4-1BB及淋巴细胞亚群的表达。结果 AIL患儿外周血4-1BB的表达及CD3+、CD4+、CD8+的表达均高于URI患儿及对照组,差异有统计学意义(P<0.05);URI患儿与对照组间的差异则无统计学意义(P>0.05)。三组外周血CD19+CD23+的表达的差异无统计学意义(P>0.05)。AIL患儿外周血4-1BB的表达与CD3+的表达成显著正相关(r=0.73,P<0.05)。结论4-1BB可能参与了AIL的发病。AIL患儿异常增多的T细胞可能不具备活化B细胞的功能。Objective To investigate expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis. Methods Flow cytometry （FCM） was applied to detect the expression of 4-1BB and lymphocyte subsets in peripheral blood of 15 cases of acute infectious lymphocytosis and 20 cases of acute upper respiratory infection, and 20 healthy children. Results The expression of 4-1BB and CD3＋, CD4＋and CD8＋lymphocytes were higher in acute infectious lymphocytosis group than those in acute upper respiratory infection group and healthy control group （P〈0.05）. There was no sig-niifcant difference of CD19＋CD23＋lymphocytes among three groups （P〉0.05）. A positive correlation was found between 4-1BB expression and CD3＋ lymphocytes expression in acute infectious lymphocytosis group （r=0.73, P〈0.05）. Conclusions The abnormal expression of 4-1BB may play a pathological role in the development of acute infectious lymphocytosis. T cells in chil-dren with acute infectious lymphocytosis may not function to activate B cells.

关 键 词：淋巴细胞亚群 急性传染性淋巴细胞增多症 流式细胞术 儿童 

分 类 号：R725.1[医药卫生—儿科]