微RNA在动脉粥样硬化中的研究新进展  

Research Progress of MicroRNA in Atherosclerosis

作　　者：李晶晶[1] 樊光辉[1] 何亚雄[1] 

机构地区：[1]广州军区武汉总医院神经内科,武汉430000

出　　处：《医学综述》2014年第21期3865-3867,共3页Medical Recapitulate

基　　金：2010年度军队中医药科研专项基金课题(10ZYZ117)

摘　　要：近年来,不同的微RNA(miRNA)在心血管系统中的关键作用得到广泛认识。miRNA是在转录后水平调控基因表达的一种内源性RNA序列,通过调控编码基因的表达,实现对机体不同阶段基因表达的调控。是可相对稳定存在于循环血液中的新生物标志物,检测其表达谱可明确其与动脉粥样硬化(AS)的相关性。通过研究相关miRNA的组成及其在AS中的作用机制,将对AS的诊断、治疗及心血管疾病的风险预测等方面提供新的方向。In the past few years, the crucial role of different microRNA （miRNA） in the cardiovascular system has been widely recognized, miRNA are small endogenous sequences of RNA that regulate gene expression at posttranscriptional level. Recently, it was discovered that extracellular miRNAs circulate in the bloodstream and that such circulating miRNAs are remarkably stable. This has raised the possibility that miRNAs may be probed in the circulation and can serve as novel diagnostic markers. In this review,we will discuss the composition of miRNAs and mechanism of miRNAs effects on atherosclerotic disease, which will provide a new direction to promote diagnosis and treatment of atherosclerosis,and cardiovascular risk prediction.

关 键 词：动脉粥样硬化 微RNA 心脏生物学 

分 类 号：R543.5[医药卫生—心血管疾病]