病毒性心肌炎发病机制研究进展  

Research Progress of Pathogenesis of Viral Myocarditis

作　　者：孙鹤[1] 于建才[1] 赫嘉惠 赵德超[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心内八病房,哈尔滨150001

出　　处：《医学综述》2014年第21期3868-3870,共3页Medical Recapitulate

基　　金：黑龙江省自然科学基金(D201070)

摘　　要：病毒性心肌炎是指各种病毒引起的局灶性或弥漫性心肌细胞变性、坏死,伴有炎症细胞浸润,从而导致心肌损伤、心功能障碍和心律失常的一种疾病。大部分患者可痊愈,但是一部分患者会发展为慢性炎症或扩张型心肌病。目前病毒性心肌炎的发病机制仍未完全阐明,主要包括病毒入侵、免疫反应、细胞因子相互作用、细胞凋亡、活性氧类等。该文就其发病机制的研究进展予以综述。Viral myocarditis is a disease caused by multiple viruses. It is a kind of local or diffuse denaturation and necrosis of myocardial, accompanied by inflammatory cell infiltration, which will lead to myocardial injury,cardiac dysfunction and arrhythmia. Most patients can recover without sequelae, but a subset of patients will progress to chronic inflammatory and dilated cardiomyopathy. Currently, the pathogenesis of viral myocarditis still remains unclear,which mainly includes virus invasion,immune responses,the interactions of cytokines, apoptosis and reactive oxygen species. Here is to make a review of the research progress in pathogenesis of viral myocarditis.

关 键 词：病毒性心肌炎 发病机制 细胞凋亡 活性氧类 

分 类 号：R542.21[医药卫生—心血管疾病]