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机构地区:[1]江苏省扬州市第一人民医院,江苏扬州225001 [2]南京医科大学附属南京儿童医院,江苏南京210093
出 处:《儿科药学杂志》2014年第11期23-25,共3页Journal of Pediatric Pharmacy
摘 要:目的:研究完全水解蛋白配方奶(CHPF)对早产儿生长发育、喂养安全性的影响。方法:采用前瞻性随机对照研究方法,将我院NICU收治的早产儿40例分为CHPF组及标准早产儿配方奶组(SPF组),比较两组的体格发育指标、喂养不耐受率、达完全肠道喂养时间、静脉营养使用时间、恢复出生体质量时间。结果:与SPF组比较,CHPF组喂养不耐受发生率降低(6.25%vs 33.33%),每天体质量增长[(18.06±1.84)g vs(13.58±1.74)g]、每周身长增长[(1.07±0.14)cm vs(0.89±0.18)cm]、每周头围增长[(0.78±0.12)cm vs(0.52±0.09)cm]加快,达全胃肠喂养时间[(16.9±4.4)d vs(21.1±5.0)d]、静脉营养时间[(11.6±2.1)d vs(14.1±2.0)d]及恢复出生体质量时间[(7.4±0.8)d vs(9.3±1.8)d]缩短,差异均有统计学意义(P均<0.05)。结论:CHPF能够促进胃排空,改善早产儿喂养不耐受,并使其更早达到全胃肠道喂养,从而促进早产儿生长发育;CHPF可用于早产儿开奶。Objective: To investigate the effect of completely hydrolyzed protein formula (CHPF) milk on the growth and the safety in premature infant. Methods: A prospective randomized study was performed, 40 premature infants who treated in NICU were randomly divided into CHPF group (n = 16) and standard premature infant formula milk group (SPF group) (n =24). Compared the physical development index, the incidence of feeding intolerance, the time of intravenous nutrition and regaining the birth weight between two groups. Results: Compared winh SPF group, the incidence of feeding intolerance in CHPF group was much lower (6.25% vs 33.33% ), the growth velocity of body weight in one day [ ( 18.06±1.84) g/d vs ( 13.58± 1.74 ) g/d ], body length in one day [ ( 1.07 ±0.14) cm/w vs (0.89±0.18) cm/w] , head circumference in one week [ (0.78±0.12) cm/w vs (0.52±0.09) cm/w] in CHPF group were increased more quickly. For the time to achieve full enteral feeding [ (16.9±4.4) d vs (21.1 ±5.0) d], regain the birth weight [ (7.4±0.8) d vs ( 9.3±1.8 ) d ] and the duration of parenteral nutrition [ ( 11.6±2.1 ) d vs ( 14.1 ±2.0 ) d ] in CHPF group was shorter than SPF group. Conclusion: CHPF can improve gastric emptying and feeding tolerance, and enable a more rapid establishment of full enteral feeding in preterm infant compared with SPF, so it can be used as the early opening of milk.
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