复方积雪草苷凝胶贴膏的制备工艺研究  

Preparation Process of Compound Asiaticoside Gel Plasters

作　　者：李旸[1] 陈晨[1] 李银科[1] 胡晓[2] 廖祥茹[1] 韩亮[1] 陈鹰[1] 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]湖北医药学院附属人民医院药学部

出　　处：《中国药师》2014年第10期1672-1674,共3页China Pharmacist

基　　金：湖北省卫生厅课题(编号:JX6B27)

摘　　要：目的:筛选复方积雪草苷凝胶贴膏的处方,确定最佳制备工艺。方法:采用正交设计法,以凝胶贴膏的初黏力、持黏力、综合外观为考察指标,对复方积雪草苷凝胶贴膏进行综合评分,考察不同基质辅料比例对复方积雪草苷凝胶贴膏的影响,优选最佳处方工艺。结果:最佳处方基质配比为甘羟铝:EDTA:甘油:CMC-Na=0.25:0.05:45:1。结论:按照最佳工艺条件制备的复方积雪草苷凝胶贴膏黏附力好,外观涂布均匀,能适应大生产的需要。Objective： To optimize the formula of compound asiaticoside gel plasters, and determine the optimal preparation process. Methods：Using the initial adhesion, viscosity and appearance as the indices, the gel plasters were evaluated by orthogonal design in order to study the effects of various base ratios on the preparation and screen the optimal formula and preparation process. Re-sults：The optimal formula was dihydroxyaluminium aminoacetate∶EDTA∶glycerol∶CMC-Na of 0. 25∶0. 05∶45∶1. Conclusion： Com-pound asiaticoside gel plasters with the optimal formula and preparation technique show good adhesion and uniformity, which can meet the need of large-scale production.

关 键 词：复方积雪草苷 凝胶贴膏 基质 制备工艺 

分 类 号：R283.649[医药卫生—中药学]