百令胶囊联合注射用灯盏花素对维持性腹膜透析患者微炎症状态的影响  

Influence of Bailing Capsules Combined with Breviscapine Injections on Micro-inflamation in Patients with Peritoneal Dialysis

作　　者：张红[1] 

机构地区：[1]郑州大学附属郑州中心医院肾病风湿免疫科,郑州450007

出　　处：《中国药师》2014年第10期1705-1707,共3页China Pharmacist

摘　　要：目的:观察百令胶囊联合注射用灯盏花素对维持性腹膜透析患者微炎症的影响。方法:65例维持性腹膜透析6个月以上患者分为观察组33例和对照组32例。两组均予维持腹膜透析,并给予常规对症治疗。对照组在此基础上加用灯盏花素,观察组在对照组基础上再加用百令胶囊。治疗2周后,比较两组患者治疗前后血肌酐、尿素、血浆白蛋白、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)等指标水平。结果:治疗后两组血肌酐、尿素均较治疗前明显降低(P<0.05),血浆白蛋白明显升高(P<0.05),且观察组血肌酐水平明显低于对照组(P<0.05),血浆白蛋白明显高于对照组(P<0.05)。两组hsCRP、IL-6水平较治疗前均有明显降低(P<0.01或0.05),且观察组hs-CRP、IL-6水平明显低于对照组(P<0.01)。结论:百令胶囊联合注射用灯盏花素对持续性腹膜透析患者微炎症状态控制良好,优于单用灯盏花素。Objective：To explore the effects of Bailing capsules combined with breviscapine injections on the micro-inflammation in the patients with peritoneal dialysis. Methods：Sixty-five patients with peritoneal dialysis for more than 6 months were randomly di-vided into the treatment group （33 patients） and the control group （32 patients）. The two groups were still given peritoneal dialysis and treated with the conventional symptomatic treatment combined with breviscapine, while in the treatment group, Bailing capsules were given additionally. Before and after the 2-week treatment, serum creatinine, urea, plasma albumin, hs-CRP and IL-6 were exam-ined and compared in the two groups. Results：After the treatment, serum creatinine and urea in the two groups were significantly de-creased（P〈0. 05）, and plasma albumin was increased significantly（P〈0. 05）, and the changes in the treatment group were more no-table than those in the control group （P〈0. 05）. After the treatment, the average levels of hs-CRP and IL-6 were decreased signifi-cantly in the two groups （P〈0. 05 or P〈0. 01）, and those in the treatment group were lower than those in the control group （P〈0. 01）. Conclusion：The combined therapy of Bailing capsules and breviscapine injections shows better clinical effects on the micro-inflammation in the patients with peritoneal dialysis than breviscapine injections alone.

关 键 词：百令胶囊 注射用灯盏花素 腹膜透析 微炎症 超敏C反应蛋白 白细胞介素-6 

分 类 号：R286[医药卫生—中药学]