乳疾灵颗粒辐照前后淫羊藿苷含量变化研究  

Content Change of Icariin in Rujiling Granules after Ray Irradiation

作　　者：张振巍[1] 张娜娜 仇继玺[1] 张新民[1] 石磊[1] 

机构地区：[1]解放军第155中心医院,河南开封475003 [2]开封市中医院

出　　处：《中国药师》2014年第10期1768-1769,共2页China Pharmacist

基　　金：济南军区后勤科研计划(编号:CJN10L067)

摘　　要：目的：对比乳疾灵颗粒辐照前后淫羊藿苷含量差异。方法：采用HPLC色谱法,色谱柱为Thermo ODS-2 HYPERSIL色谱柱（250 mm ×4.6 mm,5μm）；流动相为乙腈-0.033 mol·L^-1磷酸二氢钾（30∶70）；检测波长为265 nm；流速为1.0 ml· min^-1；柱温30℃。结果：淫羊藿苷在浓度3.44~34.40μg·ml^-1范围内呈现良好的线性关系,r=0.9997（n=6）；平均回收率为98.18%,RSD=0.32%。乳疾灵颗粒辐照前后淫羊藿苷含量变化差异无统计学意义（P〉0.05）。结论：常规剂量照射处理对乳疾灵颗粒中淫羊藿苷影响较小。Objective：To compare the content of icariin in Rujiling granules before and after the ray irradiation. Methods： The column was Thermo ODS-2 HYPERSIL （250 mm × 4. 6 mm,5 μm） with the temperature of 30℃, and the mobile phase was acetoni-trile-0. 033 mol·L^-1 potassium dihydrogen phosphate（30∶70） with the flow rate of 1. 0 ml·min^-1. The detection wavelength was 265nm. Results：There was a good linear relationship within the range of 3. 44-34. 40μg·ml-1 for icariin （r=0. 999 7, n=6）. The average recovery was 98. 18% with RSD of 0. 32%（n=9）. Conclusion：The content change of icariin in Rujiling granules before and after the ray irradiation is not statistically significant, which illustrates that the conventional dose irradiation has little effect on icariin.

关 键 词：乳疾灵颗粒 淫羊藿苷 辐照 含量变化 

分 类 号：R927.2[医药卫生—药学]