肥胖对初诊2型糖尿病患者大血管病变的影响  

Effect of obesity on vascular disease in patients with newly diagnosed type 2 diabetes

作　　者：朱嘉瑜[1] 唐伟[1] 俞海燕[1] 孔亚娟[1] 郭晓珍[1] 

机构地区：[1]江阴市人民医院内分泌病科,江苏省214400

出　　处：《江苏医药》2014年第21期2557-2559,共3页Jiangsu Medical Journal

摘　　要：目的探讨肥胖对初诊2型糖尿病(T2DM)患者大血管病变的影响。方法根据体重指数(BMI)将90例初诊T2DM患者均分为肥胖组(A组,BMI≥28)、超重组(B组,24≤BMI≤27.9)和体重正常组(C组,18.5≤BMI≤23.9)。采用无创动脉硬化检测装置测定肱踝脉搏波传导速度(ba-PWV)和踝肱指数(ABI),血管超声检测颈动脉斑块形成率,同时测定糖化血红蛋白(HbA1c)、血压和血脂。结果 A组和B组ba-PWV、颈动脉斑块形成率、腰围、收缩压(SBP)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)水平均高于C组(P<0.05);A组舒张压水平(DBP)高于C组(P<0.05)。A组和B组颈动脉斑块形成率高于C组(40%和23%vs.10%)(P<0.05)。TG与ba-PWV呈正相关(r=0.47,P<0.05),TG是ba-PWV的独立危险因素。结论肥胖是初诊T2DM患者外周大血管发生硬化并形成斑块的重要促进因素。Objective To investigate the impact of obesity on vascular disease in the patients with newly diagnosed type 2diabetes（T2DM）.Methods According to body mass index（BMI）,90 newly diagnosed T2 DM patients were assigned into three groups of A（BMI≥28,30cases）,B（24≤BMI≤27.9,30cases）and C（18.5≤BMI≤23.9,30cases）.Arterial stiffness was measured by brachial-ankle pulse wave velocity（ba-PWV）and ankle-brachial index（ABI）.Carotid artery plaque was detected by vascular ultrasound.Glycosylated hemoglobin（HbA1c）,fasting plasma glucose,blood pressure,lipids were measured.Results Ba-PWV,carotid arterial plaque formation rate,waistline,systolic blood pressure（SBP）,triglycerides（TG）,lipoprotein cholesterol（LDL-C）in groups of A and B were higher than those in group C（P〈0.05）,and diastolic blood pressure（DBP）in group A was higher than that in group C（P〈0.05）.The carotid arterial plaque formation rate was higher in groups of A and B than that in group C（40% and 23% vs.10%）（P〈0.05）.TG was positively correlated to ba-PWV（r=0.47,P〈0.05）.TG was an independent risk factor for ba-PWV（r=0.47,P〈0.05）.Conclusion Obesity promotes the formation of atherosclerosis and plaque in newly diagnosed T2 DM patients.

关 键 词：肥胖 2型糖尿病 血管病变 

分 类 号：R587[医药卫生—内分泌]