地佐辛对依托咪酯诱发肌阵挛的预防效果  

Preventive effect of dezocine pretreatment on etomidate-induced myolonus

作　　者：张擎[1] 何亮[1] 刘存明[2] 

机构地区：[1]南京医科大学第二附属医院麻醉科,江苏省210011 [2]南京医科大学第一附属医院麻醉科

出　　处：《江苏医药》2014年第21期2601-2603,共3页Jiangsu Medical Journal

摘　　要：目的评价地佐辛对依托咪酯诱发肌阵挛的预防效果。方法 100例全麻择期手术患者随机均分为四组,分别静脉注射生理盐水(A组)、地佐辛0.05mg/kg(B组)、地佐辛0.075mg/kg(C组)和地佐辛0.1mg/kg(D组),1min后静脉注射依托咪酯0.3mg/kg实施麻醉诱导。持续观察2min,记录肌阵挛发生情况。结果 B、C和D组患者注射依托咪酯后肌阵挛反应的发生率分别为40%、20%和0,均低于A组的76%(P<0.01)。A组肌阵挛程度重于B组和C组(P<0.01)。麻醉诱导期未发生严重的低血压和心动过缓。结论提前1min注射地佐辛0.1mg/kg可安全有效地降低依托咪酯诱导的肌阵挛的发生率。Objective To investigate the preventive effect of dezocine pretreatment on etomidate-induced myolonus.Methods A total of 100 patients undergoing selective operation under general anesthesia was equally randomized into 4groups,who at 1 minute prior to induction were preinjected normal saline（group A）,dezocine 0.05mg/kg（group B）,dezocine 0.075mg/kg（group C）or dezocine 0.1mg/kg（group D）.Etomidate 0.3mg/kg was injected and the occurrence and severity of myoclonus were assessed in two minutes after etomidate injection.Results The incidence rates of myoclonic reaction in groups of B,C and D were 40%,20% and 0,respectively,which were significantly lower than 76%in group A（P〈0.01）.The intensity of myoclonus was more severe in group A than that in groups of B and C（P〈0.01）.No obvious hypotension and bradycardia occurred in 4 groups.Conclusion Preinjection of dezocine 0.1 mg/kg at 1 minute before etomidate administration can effectively and safely reduce the incidence of etomidate-induced myoclonus.

关 键 词：依托咪酯 地佐辛 肌阵挛 

分 类 号：R614[医药卫生—麻醉学]