醚链桥联的咪唑[1,5-a]吡啶鎓盐的合成及其原位催化Suzuki偶联反应  

Synthesis of Imidazo[1,5-a] pyridinium Salts Bridging by Ether Chain and Catalyzed Suzuki Cross-coupling Reaction in Situ

作　　者：赵波[1] 张仕禄[1] 罗杰伟[1] 冉利[1] 

机构地区：[1]川北医学院基础医学院分析中心,四川南充637000

出　　处：《化学试剂》2014年第11期1029-1032,共4页Chemical Reagents

基　　金：川北医学院科研基金资助项目(CBY13-A-QN38)

摘　　要：以8-羟基喹哪啶为原料,经过取代、氧化得到通过醚链桥联的喹啉衍生物。该衍生物与胺发生三组分串联反应合成了标题化合物,其结构经1HNMR、13CNMR确证。该标题化合物应用于原位催化Suzuki偶联反应,并有较高的活性。Quinoline derivatives which bridged by ether chain was synthesized from 8-hydroxyquinaldine by formation of substitution and oxidation. Imidazo[1,5-a]pyridinium salts that reacted with amine were prepared by a facile three-component coupling. The structure was confirmed by1 HNMR and13CNMR. Imidazo[1,5-a]pyridinium salts were used catalyzing Suzuki cross-coupling reaction in situ. Imidazo[1,5-a]pyridinium salts exhibited more catalytic activity.

关 键 词：8-羟基喹哪啶 咪唑[1 5-a]吡啶鎓盐 醚链 

分 类 号：O626.5[理学—有机化学] O625.8[理学—化学]