担子菌薄皮干酪菌中两个新的倍半萜(英文)  

Two new sesquiterpenoids from basidiomycete Tyromyces chioneus

作　　者：郭华[1] 冯涛[2] 李正辉[2] 刘吉开[2] 

机构地区：[1]鞍山师范学院化学与生命科学学院,辽宁鞍山114005 [2]中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201

出　　处：《药学学报》2014年第11期1578-1581,共4页Acta Pharmaceutica Sinica

基　　金：supported by the National Natural Science Foundation of China(U1132607,81102346);Youth Innovation Promotion Association of CAS(2011312D11019)

摘　　要：采用硅胶、RP-18、Sephadex LH-20等多种材料进行分离纯化,通过理化方法和波谱分析进行结构鉴定,从担子菌薄皮干酪菌(Tyromyces chioneus)发酵液的乙酸乙酯提取部位分离并鉴定了4个化合物,它们分别为:tyromol A(1)、tyromol B(2)、15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene(3)和agripilol C(4)。其中化合物1和2为新的倍半萜,化合物3和4均为首次从该真菌中分离得到。Two new sesquiterpenoids,named as tyromols A and B（1 and 2）,were isolated from cultures of basidiomycete Tyromyces chioneus,along with two previously reported 15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene（3） and agripilol C（4）. Compounds 1-4 were separated and purified by silica gel,RP-18,Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of extensive spectroscopic analysis including IR,MS,1D and 2D NMR experiments.

关 键 词：薄皮干酪菌 倍半萜 tyromolA tyromolB 

分 类 号：R284[医药卫生—中药学]