CD64指数在新生儿脓毒症早期诊断中的意义  

Significance of CD64 index for early diagnosis of neonatal sepsis

作　　者：阮莉莉[1] 杜俊君[2] 林艳[1] 楼红萍 

机构地区：[1]杭州师范大学附属医院儿科,杭州310015 [2]苏州市立医院儿科,苏州215008

出　　处：《上海交通大学学报（医学版）》2014年第10期1503-1505,1510,共4页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的评估CD64指数在新生儿脓毒症早期诊断中的意义。方法采用前瞻性病例对照研究方法进行分析。41例新生儿患儿分为确诊脓毒症组(n=14)、临床脓毒症组(n=15)和对照组(n=12),各组患儿均在入院24 h内采集静脉血样,采用流式细胞术检测CD64指数。结果流式细胞仪检测结果显示:确诊脓毒症组、临床脓毒症组和对照组的CD64指数分别为12.93±4.08,9.51±2.21和2.98±0.72。与对照组比较,确诊脓毒症组和临床脓毒症组CD64指数显著增高(t=8.97,P=0.00;t=6.27,P=0.00);确诊脓毒症组CD64指数显著高于临床脓毒症组(t=2.39,P=0.023)。结论 CD64指数的检测有助于新生儿脓毒血症的早期诊断,并可区分感染的严重程度,为临床正确治疗提供重要依据。Objective To evaluate the significance of the CD64 index for the early diagnosis of neonatal sepsis.Methods The prospective case-control study was adopted to conduct the analysis. A total of 41 neonatal patients were divided into the documented sepsis group（ n = 14）, clinical sepsis group（ n = 15）, and control group（ n = 12）. Venous blood specimens of all patients were collected with in 24 h after admission.The CD64 index was measured by the flow cytometry. Results Results of the flow cytometry showed that the CD64 indexes of the documented sepsis group, clinical sepsis group, and control group were 12. 93 ± 4. 08, 9. 51 ±2. 21, and 2. 98 ± 0. 72, respectively.Compared to the control group, the CD64 indexes of the documented sepsis group and clinical sepsis group were significantly higher（ t = 8. 97, P = 0. 00; t = 6. 27, P = 0. 00）.The CD64 index of the documented sepsis group was significantly higher than that of the clinical sepsis group（ t = 2. 39,P = 0. 023）. Conclusion Detection of CD64 contributes to the early diagnosis of neonatal sepsis,identifies the degree of infection, and provides an important evidence for appropriate clinical treatment.

关 键 词：脓毒症 CD64 流式细胞术 新生儿 

分 类 号：R720.597[医药卫生—急诊医学]