MicroRNA——急性肺损伤的新型调控分子  

MicroRNA:a novel regulatory molecule of acute lung injury

作　　者：曹永梅[1] 李颖川[1] 

机构地区：[1]上海交通大学附属第六人民医院麻醉科,上海200233

出　　处：《上海交通大学学报（医学版）》2014年第10期1539-1542,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81272145);上海市卫生局基金(2009089)~~

摘　　要：急性肺损伤(ALI)是以严重肺部炎症为特征的常见的复杂性疾病。微小RNA(miRNA)作为一类新型的基因调控分子,在许多疾病包括ALI的病理过程中发挥着至关重要的作用。在肺损伤和修复过程中,特定种类的miRNA异常表达,并通过影响其靶基因的表达调控炎症通路和免疫反应。因此,miNRA可作为ALI的生物学标志物。文章就miNRA在ALI中的作用进行综述。Acute lung injury（ ALI） is a common and complex disease characterized by severe pulmonary inflammation. As a new type of gene regulator, microRNA（ miRNA） plays vital roles in a wide range of human disorders and diseases, including ALI. During the process of lung injury and repair, certain kinds of miRNA express abnormally and can modulate inflammation pathways as well as immune response by affecting expressions of target genes.Therefore, miRNA can serve as biological markers for ALI. This paper reviews the effects of miRNA on ALI.

关 键 词：微小RNA 急性肺损伤 炎症 免疫反应 

分 类 号：R563.8[医药卫生—呼吸系统]