类风湿性关节炎滑膜超声造影定量分析与临床及实验室检查指标的相关性研究  

Correlation Between Quantitative Results of Contrast-enhanced Ultrasonography and Clinical and Laboratory Indexes for Synovium of Patients with Rheumatoid Arthritis

作　　者：张凌燕[1] 向茜[1] 唐远姣[1] 冷钱英 邱逦[1] 

机构地区：[1]四川大学华西医院超声科,成都610041

出　　处：《四川大学学报（医学版）》2014年第6期1001-1004,共4页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.81271585)资助

摘　　要：目的探讨超声造影定量分析结果与类风湿性关节炎临床及实验室检查指标之间的相关性。方法病例组(35例类风湿性关节炎患者)和对照组(10例正常成年人)均行DAS28评分和实验室检查血沉(ESR)、C反应蛋白(CRP),同时行超声检查并对滑膜增厚最明显关节做超声造影(CEUS);将超声造影定量分析数据、造影后测量的滑膜厚度与DAS28评分、ESR及CRP进行统计学相关分析。结果超声造影定量分析参数中,峰值强度(PI)与曲线下面积(AUC)分别与类风湿性关节炎患者的ESR、CRP、DAS28评分呈正相关(P<0.01);其余超声造影定量分析各参数与ESR、CRP和DAS28评分无相关性(P>0.05);造影后滑膜厚度与ESR、CRP、DAS28评分相关有统计学意义(P<0.01)。结论超声造影后滑膜厚度、造影定量分析参数PI与AUC可作为衡量类风湿性关节炎炎症活动度的指标,为诊断和治疗评估提供影像学的定量证据。Objective To determine the correlation between quantitative results of contrast-enhanced ultrasound and clinical and laboratory index for synovium of patients with rheumatoid arthritis（RA）.MethodsThirty-five RA patients participated in this study,with ten normal adults serving as controls.They were given a score of DAS28 and underwent laboratory tests,including erythrocyte sedimentation rate（ESR）and C-reactive protein（CRP）.Contrast-enhanced ultrasound examinations were performed to detect thickness of synovium（2Dand Power Dopple）.Results Peak intensity（PI）and area under the curve（AUC）were positively correlated with ESR,CRP and DAS28 score,respectively（P 〉0.01）.The rest of ultrasound parameters had no significant correlations with ESR,CRP and DAS28score（P〈0.05）.Synovium thickness identified by contrast-enhanced ultrasound had significant correlations with ESR,CRP and DAS28score（P〈 0.01）.Conclusion Synovium thickness determined by contrast-enhanced ultrasound,PI and AUCcan serve as an index estimating inflammatory activity of RA,and provide evidence for clinical diagnosis and treatment.

关 键 词：类风湿性关节炎 超声造影 实验室检查指标 定量分析 DAS28 

分 类 号：R593.22[医药卫生—内科学]