氯甲基化聚苯乙烯负载修饰L-脯氨酸催化不对称Aldol反应研究  

Asymmetric Aldol reaction catalyzed by chloromethylated polystyrene-supported modified L-proline

作　　者：赵文善[1] 贾晓波[1] 宋玉杰[2] 

机构地区：[1]河南大学化学化工学院,河南开封475001 [2]安阳钢铁集团有限公司动力厂,河南安阳455004

出　　处：《化学研究》2014年第6期632-635,共4页Chemical Research

基　　金：河南省科技厅自然科学基金资助(082300420010)

摘　　要：以氯甲基化聚苯乙烯为载体,分别以氨基胍、三聚氰胺和4,4′-二氨基苯磺酰苯胺(DASA)为连接臂,合成了三种负载修饰L-脯氨酸催化剂,并且将其用于催化不对称Aldol反应,探索了溶剂和底物对其催化性能的影响,并考察了其重复使用性能.结果表明,DASA负载修饰L-脯氨酸催化剂具有较好的催化活性和选择性,相应的最高产率达83%,e.e.值达86%.Three kinds of supported L-proline catalysts were synthesized with chloromethylated polystyrene as the carrier and aminoguanidine,melamine,or 4,4′-diamino-benzene sulfonyl aniline（DASA）as the connection arm.As-synthesized products were adopted to catalyze asymmetric Aldol reaction,and their catalytic performances were evaluated in relation to the effects of solvent and substrate.Moreover,the reusabilities of the three kinds of supported catalysts were also investigated.Results indicate that the supported L-proline catalyst with DASA as the connection arm exhibits good catalytic activity and selectivity for the asymmetric Aldol reaction,and it provides a maximum yield of 83%and an e.e.value of 86%,respectively.

关 键 词：氯甲基化聚苯乙烯 氨基胍 三聚氰胺 DASA L-脯氨酸 不对称ALDOL反应 

分 类 号：O621.3[理学—有机化学]