加巴喷丁治疗腹膜透析患者皮肤瘙痒及睡眠障碍的临床研究  

Clinical research of gabapetin in treatment of cutaneous pruritus and sleeping disorder in peritoneal dialysis patients

作　　者：施珍[1] 黄文[1] 潘敏[1] 王红[1] 周志宏[1] 

机构地区：[1]温州医科大学附属第二医院肾内科,浙江温州325000

出　　处：《中国现代医生》2014年第32期28-30,共3页China Modern Doctor

基　　金：浙江省自然科学基金(Y2100650)

摘　　要：目的观察加巴喷丁治疗腹膜透析患者(CAPD)皮肤瘙痒及睡眠障碍的临床疗效。方法选取我院行持续不卧床腹膜透析患者中有皮肤瘙痒和睡眠障碍的患者22例,随机分为试验组和对照组各11例,试验组患者透析后每日晚间服用加巴喷丁300 mg,对照组每日晚间服用盐酸西替利嗪片10 mg。12周后根据视觉模拟评分(VAS)、匹兹堡睡眠质量指数量表(PSQI)进行疗效评定。结果 (1)试验组治疗后皮肤瘙痒症状明显改善。试验组用药前平均VAS得分(8.64±1.22),加巴喷丁治疗12周后平均VAS得分(1.34±0.98),VAS得分值平均下降(7.12±1.27)。对照组用药前平均VAS得分(8.12±1.42),对照组用药后平均VAS得分(7.35±1.56),VAS得分值平均下降(1.22±1.50),两组VAS得分下降值比较有显著统计学差异(P<0.01)。(2)试验组治疗后睡眠障碍明显改善。试验组治疗后除催眠药物外的各项睡眠质量指标及总分分数均降低,与治疗前比较差异有统计学意义(P<0.01)。除睡眠质量外,对照组的各项睡眠质量指标及总分治疗前后比较差异无统计学意义(P>0.05)。结论短期服用加巴喷丁能够有效治疗腹膜透析患者的皮肤瘙痒,同时改善睡眠障碍,提高患者的生活质量。Objective To observe the treatment effect of gabapetin on cutaneous pruritus in peritoneal dialysis patients. Methods Twenty-two CAPD patients with continuous cutaneous pruritus and sleeping disorder were randomly divided into treatment group（gabapentin 300 mg before sleep on dialysis day） and control group（cetirizine 10 mg before sleep）. The efficacy was assessed by visual analogue score （VAS） and Pittsburgh Sleep Quality Index （PSQI）. Results （1）After treatment,the frequency and degree of pruritus in patients of treatment group significantly reduced, the VAS score in treatment group decreased from （8.64±1.22） to （1.34±0.98）,compared to that of （8.12±1.42） to （7.35±1.56） in control group （P〈0.01）; （2）After treatment,the sleeping disorder in patients of treatment group significantly improved. The PSQI scores in treatment group significantly decreased （P〈0.01）. Conclusion Gabapentin is an effective drug for cutaneous pruritus and sleeping disorder in peritoneal dialysis patients ,and it can improve the quality of life of patients.

关 键 词：加巴喷丁 腹膜透析 皮肤瘙痒 睡眠障碍 

分 类 号：R692.5[医药卫生—泌尿科学]