Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes  

作　　者：NA Li Xin YAN Bo Lin JIANG Shuo CUI Hong Li LI Ying SUN Chang Hao 

机构地区：[1]Department of Nutrition and Food Hygiene,Public Health College,Harbin Medical University [2]The 1st affiliated hospital of Harbin Medical University

出　　处：《Biomedical and Environmental Sciences》2014年第11期902-906,共5页生物医学与环境科学（英文版）

基　　金：supported by the China Postdoctoral Science Foundation(No.2012M520774,No.2013T60393);Heilongjiang Postdoctoral Science Foundation(LBH-Z12156)

摘　　要：Whether supplementation of curcuminoids decreases serum adipocyte-fatty acid binding protein（A-FABP） level and whether this decrease benefits glucose control is unclear.One-hundred participants（n=50 administered curcuminoids,n=50 administered placebo） from our previous report on the effect of curcuminoids on type 2 diabetes in a 3-month intervention were assessed for levels of serum A-FABP,oxidative stress,and inflammatory biomarkers.Curcuminoids supplementation led to significant decreases in serum A-FABP,C-reactive protein（CRP）,tumor necrosis factor-α,and interleukin-6 levels.Curcuminoids supplementation also significantly increased serum superoxide dismutase（SOD） activity.The change in serum A-FABP levels showed positive correlations with changes in levels of glucose,free fatty acids（FFAs）,and CRP in subjects supplemented with curcuminoids.Further stepwise regression analysis showed that A-FABP was an independent predictor for levels of FFAs,SOD,and CRP.These results suggest that curcuminoids may exert anti-diabetic effects,at least in part,by reductions in serum A-FABP level.A-FABP reduction is associated with improved metabolic parameters in human type 2 diabetes.Whether supplementation of curcuminoids decreases serum adipocyte-fatty acid binding protein（A-FABP） level and whether this decrease benefits glucose control is unclear.One-hundred participants（n=50 administered curcuminoids,n=50 administered placebo） from our previous report on the effect of curcuminoids on type 2 diabetes in a 3-month intervention were assessed for levels of serum A-FABP,oxidative stress,and inflammatory biomarkers.Curcuminoids supplementation led to significant decreases in serum A-FABP,C-reactive protein（CRP）,tumor necrosis factor-α,and interleukin-6 levels.Curcuminoids supplementation also significantly increased serum superoxide dismutase（SOD） activity.The change in serum A-FABP levels showed positive correlations with changes in levels of glucose,free fatty acids（FFAs）,and CRP in subjects supplemented with curcuminoids.Further stepwise regression analysis showed that A-FABP was an independent predictor for levels of FFAs,SOD,and CRP.These results suggest that curcuminoids may exert anti-diabetic effects,at least in part,by reductions in serum A-FABP level.A-FABP reduction is associated with improved metabolic parameters in human type 2 diabetes.

关 键 词：FABP superoxide lowering Glucose placebo interleukin assessed hundred exert adipocyte 

分 类 号：R587.1[医药卫生—内分泌]