英山县手足口病爆发高峰期病原学及流行病学观察  

Aetiologicai and epidemic analysis of hand-foot-mouth disease of Yingshan County in the peak outbreak period of 2013

作　　者：高岭 郑伦和 郑程 饶正良 

机构地区：[1]英山县人民医院输血科,湖北英山438700 [2]英山县人民医院检验科 [3]英山县人民医院感染科

出　　处：《临床血液学杂志（输血与检验）》2014年第5期865-867,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的：了解英山县2013-04-2013-05间手足口病爆发高峰期病原学及流行病学特征，为本地区手足口病的防治提供依据。方法：采集109例手足口病患者咽拭子标本，采用实时荧光定量PCR方法进行肠道病毒通用型、肠道病毒71型（EV71）和柯萨奇病毒A16型（CA16）的核酸检测。结果：肠道病毒通用型阳性81例，阳性率为74．3％；EV71病毒阳性63例，阳性率为57．8％；CA16阳性19例，阳性率为17．4％；其中EV71和CA16双阳性12例，阳性率为11．0％。此次爆发高峰期的发病患者年龄集中在1～4岁儿童，并且男性患儿明显多于女性，以散居儿童和幼托儿童为主，EV71亚型发热患者所占比率要显著高于CAl6亚型。结论：英山县2013年手足口病高峰期的主要病原体是EV71亚型，了解患者手足口病感染的病原体亚型及流行病学特征。Objective：To understand the characteristics of aetiology and epidemiology of hand-foot-mouth dis- ease（HFMD） of Yingshan County in the peak outbreak period of 2013. Method： Throat swab samples were col- lected from 109 HFMD cases,and Real-time PCR were executed to detect nucleic acid. Result： Among 109 HFMD samples, 74.3% were infected by universal enterovirus virus, 57.8% were infected by EV71,17.4% were infec- ted by CA16, and 11% were cases infected by both EV71 and CA16. The peak incidence of HFMD appeared in the age groups of 1-4 years and most of them were from home and kindergarten, and the number of boys was lar- ger than that of girls. Fever was significantly more frequent in patients with EV71 than patients with CA16 infec- tion. Conclusion： HMFD in Yingshan County were mainly caused by EVT1 during the peak outbreak period of 2013. Understanding the composition of pathogen and characteristics of epidemiology will provide laboratory data for the epidemic control and patient care.

关 键 词：手足口病 病原学 流行病学 肠道病毒71型 柯萨奇病毒A16型 

分 类 号：R512.5[医药卫生—内科学]