Junier血型系统  

Junier blood group system

作　　者：李树中[1] 卞洁[1] 徐姿[1] 方莹[1] 姚永良[1] 吴建红[1] 倪强[1] 张健[1] 李凌波[1] 

机构地区：[1]昆山市第一人民医院输血科,江苏昆山215300

出　　处：《临床血液学杂志（输血与检验）》2014年第5期913-915,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：Junier血型系统是一个新确立的血型系统，2012年由ISBT确认Junier血型系统命名JR，数字032。是由美国佛蒙德大学的约尼奥尔（Junier）最早报道而命名的，是ABC转运蛋白超家族成员G亚族的2号转运蛋白。JR抗原有6次穿膜结构，在膜外有3个环，JR抗原在膜外环上。JR抗原是一种跨膜的ABCG2转运蛋白，分子大小只有P糖蛋白的一半，也被称为“半分子转运蛋白”。1998年Doyle从耐药的乳腺癌细胞中发现了ABCG2的耐药作用，故又被称为“乳腺癌耐药蛋白”（BCRP）。ABCG2作为膜上的转运蛋白，具有将化疗药物泵出细胞外的作用，这种作用降低了药物在细胞内的浓度。在正常细胞膜上只存在少量的ABCG2，是正常机体代谢中保护细胞免受伤害的生理功能，ABCG2将细胞内有毒物质泵出细胞外。而在肿瘤是的ABCG2高表达，将治疗性药物也泵出细胞外，这与肿瘤的耐药性相关。Summary The Junier blood group system is a newly established blood group system, and named as JR, num- ber 032 by the ISBT in 2012. The Junier blood group system was first reported and named by Johnny Orr （Juni- er） ,America Vermont University, and was No. 2 transporter of G subfamily of ABC transporter super family members. JR antigen have 6 transmembrane domains, 3 rings on the outer membrane, and JR membrane antigen is in the outer ring. The JR antigen is a transmembrane ABCG2 transporter, which molecular size is only half of P glycoprotein, also known as the “semi molecular transporters”. Doyle found resistance effect of ABCG2 from drug resistant breast cancer cell in 1998, so it is also called “the breast cancer resistance protein” （BCRP）. ABCG2 as a membrane transport protein, have the clfemotherapy pump extracellular action, which reduces the concentration of the drug in cells. Only a small amount of ABCG2 exists in normal cell membrane, which plays the physiological function of normal cell metabolism from harm protection of toxic substances in the cell, which are pumped out of the cell by ABCG2. ABCG2 is high expressed in tumor, and also pump therapeutic drug out of the cell, which is related to drug resistance of tumor.

关 键 词：Junier血型系统 新的血型系统 

分 类 号：R457.1[医药卫生—治疗学]