熊去氧胆酸治疗慢性乙型肝炎重度淤胆的临床研究  

The Clinical study on therapy of chronic hepatitis B with severe cholestasis applied by ursodeoxycholic Acid

作　　者：陈立刚[1] 任建林[1] 周静平[1] 陈美娅[1] 周飞[1] 迟宝荣[2] 

机构地区：[1]厦门大学附属中山医院消化内科,厦门大学消化疾病研究所厦门市消化疾病诊治中心,福建厦门361004 [2]吉林大学第一医院肝病科,吉林长春130000

出　　处：《吉林医学》2014年第31期6894-6896,共3页Jilin Medical Journal

基　　金：厦门市医学学术与技术带头人第四批后备人选基金[项目编号:080035]

摘　　要：目的:探讨和评价熊去氧胆酸治疗慢性乙肝重度淤胆治疗的作用机制、疗效及安全性。方法:将收治的慢性乙型肝炎重度淤胆的患者136例,随机分为对照组、治疗组(加用熊去氧胆酸),治疗前进行血尿常规、血生化指标检查,以4周为1个疗程系统治疗,疗程结束后复查有关检查项目。根据临床症状改善和复查结果评价熊去氧胆酸的疗效和安全性。结果:疗程结束后,丙氨酸转氨酶(ALT)、血清总胆红素(T-BIL)的降低率之间比较,差异有统计学意义(P<0.05),而两组白蛋白(ALB)、白球蛋白比值(A/G)、γ-球蛋白比较差异无统计学意义(P>0.05)。两组治疗过程中均未出现不良反应。结论:熊去氧胆酸具有改善慢性乙型肝炎淤胆症状,降低谷丙转氨酶和血清胆红素的作用。Objective To discuss and evaluate the mechanism,therapeutic effect and safety of ursodeoxycholic acid in the therapy of chronic hepatitis B with severe cholestasis. Method 136 inpatients of chronic hepatitis B with severe cholestasis were divided into two groups at random：control group,treatment group. Routine test of blood and urine,biochemistry examination were applied before treatment,4 weeks were classified as a course of treatment,then re - examined them after the course of treatment. To evaluate the therapeutic effect and safety of ursodeoxycholic acid according to relief of clinical symptom and results of re - examination. Results Comparing treatment group with control,the decrease percent of ALT,T - BIL had significant statistic difference between them（P 〈 0. 01）,but ALB,A/ G,γ - globulin had not statistic difference between them（ P 〉 0. 05 ）. Untoward reactions were not found in the course of treatment in two groups. Conclusion Ursodeoxycholic acid can relieve clinical symptom in patients of chronic hepatitis B with severe cholestasis,decrease ALT and T - BIL.

关 键 词：熊去氧胆酸 慢性乙型肝炎 重度淤胆 

分 类 号：R512.62[医药卫生—内科学]