桐叶千金藤中的一个新氧化异阿朴啡型生物碱  

A New Oxoisoaporphine-type Alkaloid from Whole Plants of Stephania hernandifolia

作　　者：唐丽佳[1] 邓璐璐[1] 陈霞[1] 王琴[1] 张建新[1] 郝小江[1] 张援虎[1] 

机构地区：[1]贵州省中国科学院天然产物化学重点实验室,贵阳550002

出　　处：《中国药学杂志》2014年第21期1882-1884,共3页Chinese Pharmaceutical Journal

基　　金：科技部973计划前期研究专项项目(2012CB722601);国家重大科学仪器设备开发专项项目(2011YQ12003506)

摘　　要：目的研究桐叶千金藤(Stephania hernandifolia Walp.)中的化学成分。方法桐叶千金藤全草用体积分数95%乙醇溶液加热回流提取,减压回收乙醇,浓缩液加水稀释后先用HCl调节p H值,石油醚萃取,再经碱处理,石油醚、三氯甲烷萃取,得总生物碱。总生物碱利用正相硅胶、反相Rp-18、微孔吸附树脂CHP 20P、Sephadex LH-20等柱色谱方法分离纯化,通过理化性质和光谱数据进行结构鉴定。结果从桐叶千金藤中分离得到1个氧化异阿朴啡型生物碱:9-O-去甲基蝙蝠葛宁(1)。结论化合物1为一新的化合物。OBJECTIVE To study the chemical constituents of Stephania hernandifolia.METHODS The dried herbs of S.hernandifolia were extracted with 95% ethanol.After removal of the solvent,the residue was first partitioned between acid water and petroleum ether,then the aqueous layer was basified and extracted with chloroform to obtain crude alkaloids.Column chromatograghy on silica gel,Rp-18,MCI CHP 20 P,and Sephadex LH-20 were applied for the isolation and purification of the crude alkaloids fraction.The structures were elucidated by their physicochemical properties and spectral data.RESULTS One oxoisoaporphine-type alkaloid,9-Odemethylbianfugenine（ 1） was isolated from the whole plants of S.hernandifolia.CONCLUSION Compound 1 is a new compound.

关 键 词：氧化异阿朴啡型生物碱 9-O-去甲基蝙蝠葛宁 蝙蝠葛宁 防己科 桐叶千金藤 

分 类 号：R284[医药卫生—中药学]