牛樟芝浓缩胶囊对小鼠急性酒精肝损伤的保护作用  

Protective Effects of Enriched Capsules of Antrodia camphorata on Acute Alcohol Liver Injury in Mice

作　　者：王瑾[1] 徐财泉 王宫[1] 

机构地区：[1]福建省中医药研究院,福建福州350003 [2]浙江方格药业有限公司,浙江丽水323000

出　　处：《现代中药研究与实践》2014年第5期44-46,共3页Research and Practice on Chinese Medicines

基　　金：福建省战略性新兴产业发展专项产业技术开发项目(闽发改高技(2013)577号)

摘　　要：目的研究牛樟芝浓缩胶囊对小鼠急性酒精肝损伤的保护作用。方法 50只小鼠随机分成5组,空白对照组,模型对照组,牛樟芝浓缩胶囊低、中、高剂量组,每组10只,采用乙醇诱导小鼠急性肝损伤模型,观察牛樟芝浓缩胶囊对小鼠肝组织中TG,MDA,GSH含量及肝组织病理变化的影响。结果模型对照组小鼠肝组织中的TG、MDA含量高于空白对照组,GSH含量低于空白对照组,差异有统计学意义(P<0.05)。牛樟芝浓缩胶囊低、中、高剂量组TG、MDA含量低于模型对照组,GSH高于模型对照组,差异有统计学意义(P<0.05或P<0.01)。结论牛樟芝浓缩胶囊对小鼠急性酒精肝损伤具有显著保护作用。Objective To study the protective effects of Enriched Capsules of Antrodia camphorata against the acute alcohol liver injury in mice. Methods Randomly distribute 50 mices to control group, acute alcohol liver injury model group, low, middle, high dose groups of Enriched Capsules of Antrodia camphorata. Determination and comparing of liver TG, GSH activities, MDA content between groups. Result Treatment with different dose Enriched Capsules of Antrodia camphorata could increase liver GSH activities, decrease TG and MDA content in liver tissue( P < 0.05 or P<0.01). Conclusion Enriched Capsules of Antrodia camphorata showed protective effects on the acute alcohol liver injury induce by alcohol in mice.

关 键 词：牛樟芝浓缩胶囊 急性酒精肝损伤 保护作用 

分 类 号：R285.5[医药卫生—中药学]