PARP-1在苯代谢物氢醌诱导细胞凋亡中的作用  

The Role of PARP-1 in the Cell Apoptosis Induced by Benzene Metabolite Hydroquinone

作　　者：徐永春[1] 陈佳佳[1] 陈玉婷[1] 云林 唐焕文[2,3] 

机构地区：[1]广东医学院公共卫生学院,广东东莞523808 [2]广东医学院环境与健康研究所,广东东莞523808 [3]东莞市环境医学重点实验室,广东东莞523808

出　　处：《广州化工》2014年第21期3-5,17,共4页GuangZhou Chemical Industry

基　　金：国家自然科学基金(81273116);广东省自然科学基金(S2013010015153);湛江市科技计划项目(2013B01082);广东医学院科研基金(XK1414)

摘　　要：苯(benzene)是一种常见的职业性毒物和环境污染物,主要由其代谢产物氢醌(Hydroquinone,HQ)发挥毒性作用。聚腺苷二磷酸核糖聚合酶[Poly(ADP-ribose)polymerase,PARP]是一类存在于多数真核细胞内的多功能蛋白质翻译后修饰酶,其中PARP-l是研究最早、最为深入的一种。PARP-1在氢醌诱导细胞凋亡中发挥了重要作用。本文从HQ的概述、PARP-1的结构与功能以及PARP-1在HQ诱导细胞凋亡中的作用等方面做一综述,以期对苯暴露引起的各类疾病的防治提供理论指导。Benzene was a common occupational toxicology and environmental pollutants,which mainly played toxicity by its metabolite hydroquinone. Poly（ ADP-ribose） polymerase was a latter category of multifunctional protein post-translational modification enzymes existing in the majority of eukaryotic cells,while PARP-1 was studied as the earliest and most thorough one. PARP-1 played an important role in the induction of cell apoptosis by hydroquinone. Outlines of the HQ,PARP-1 structure and function as well as aspects of PARP-1 role in the induction of cell apoptosis were reviewed,expecting to prevention and treatment of various diseases caused by benzene exposure and providing theoretical guidance.

关 键 词：苯 氢醌 聚腺苷二磷酸核糖聚合酶-1 凋亡 

分 类 号：R994.6[医药卫生—毒理学]