1,2,4-三唑并[4,3-a]喹啉抗惊厥药物合成研究进展  

Progress in Synthesis of 1,2,4-Triazolo[4,3-a] Quinolone Anti-convulsion Drugs

作　　者：刘运立 周文强[1] 马小燕[1] 邹平[1] 王广途[1] 

机构地区：[1]四川农业大学理学院,四川雅安625014

出　　处：《广州化工》2014年第21期26-28,104,共4页GuangZhou Chemical Industry

基　　金：四川省教育厅一般项目资助(12ZB295);四川农业大学科研兴趣计划资助(2013118)

摘　　要：[1,2,4]三唑并[4,3-a]喹啉具有杀菌,抗结核,抗肿瘤,抗惊厥活性等多种生理活性,是抗惊厥药物研究的热点之一,有着极为广阔的研究和开发前景。本文以喹啉环和三唑环的构建方法为基础,对近年来喹啉并三唑类抗惊厥药物的合成进行了简要综述。喹啉环的构建方法包括传统的酸催化法、酶催化法、微波催化法及其他催化法;三唑环的构建主要有硫代酰胺法和氯代亚胺法,最后本文还对[1,2,4]三唑并[4,3-a]喹啉抗惊厥药物的研究前景进行了展望。[1,2,4]triazolo[4,3-a]quinoline compounds had a variety of pharmacological activities,such as antifungal,antituberculous,anticancer,anticonvulsion,and became a highlight in the field of anticonvulsants. The recent progress was reviewed according to the methods of building ring-framework. Synthetic methods of building quinoline ring included using traditional acid catalyst, enzyme catalyst, microwave catalyst and other catalyst. the methods of construction of triazole involved thioamide and chloro-imine intermediates. Finally,a vision of further study of 1,2,4-triazolo[4,3-a]quinoline anti-convulsion drugs was also proposed.

关 键 词：[1 2 4]三唑并[4 3-a]喹啉 合成 喹啉 三唑 

分 类 号：O626.2[理学—有机化学]