壬基酚对泥鳅肝脏组织的CAT、T-SOD活性的影响  

Influence of Nonylphenol on CAT and T-SOD Enzyme Activities in Loach Fish Liver

作　　者：王延琨[1] 游浩[1] 梁勇[1] 叶超[1] 祝常青[1] 刘燕群[1] 

机构地区：[1]江汉大学医学院,湖北武汉430056

出　　处：《江汉大学学报（自然科学版）》2014年第5期87-90,2,共4页Journal of Jianghan University：Natural Science Edition

基　　金：国家自然科学基金项目(20977041);湖北省高等学校优秀中青年科技创新团队项目(T201224);武汉市创新人才开发资金重大创新活动专项资助[2011]415号;武汉市人才工程入选人员科研项目择优资助(2012);湖北省自然科学基金(2012);江汉大学大学生科研项目(2013)

摘　　要：目的探讨壬基酚对泥鳅肝脏组织的CAT、T-SOD活性的影响。方法将泥鳅暴露于不同浓度的壬基酚溶液中,壬基酚分别为50、200、500、1 000μg/L,于6h测定其总超氧化物歧化酶(T-SOD)及过氧化氢酶(CAT)的活性。结果低浓度的壬基酚对SOD、CAT活性有诱导作用,随着壬基酚浓度的增加,CAT、T-SOD活性随着壬基酚浓度的增大而受到抑制。结论泥鳅肝脏组织中的CAT和T-SOD活性与水中壬基酚的浓度直接相关,随着壬基酚浓度的升高,CAT和T-SOD的活性表现均为诱导-抑制规律,泥鳅肝脏组织中CAT和T-SOD的活性均对壬基酚的早期污染具有指示作用。Objective To study the influence of nonylphenol on CAT and T-SOD enzyme activi？ties in loach liver tissue. Methods The loaches were exposed in different concentration of nonyl？phenol. The concentration of nonylphenol were 50,200,500,1 000 μg/L. Determined the activities of T-SOD and CAT after 6 hours. Results Low concentration of nonylphenol has an inducing effect on the activities of T-SOD and CAT in loach liver tissue, as the concentration of nonylphenol increased, the activities of CAT and T-SOD was restrained. Conclusion The concentration of nonylphenol in water is direct related to the CAT and T-SOD activities in the liver tissue of loach, as concentration of nonylphenol increasing, the CAT and T-SOD activities are all expressed in an inducing-repressing manner. The CAT and T-SOD activities have indicative function for early pol？lution of nonylphenol.

关 键 词：壬基酚 泥鳅 CAT T-SOD 肝脏组织 

分 类 号：R114-33[医药卫生—卫生毒理学]