降脂消斑片对鹌鹑动脉粥样硬化模型心肌及肝脏组织匀浆脂质含量的影响  

Effects of Jiangzhi Xiaoban Pill on the Myocardial and Hepatic Fat in Quails with Atherosclerosis Model

作　　者：金朝晖[1] 卜振军 邱赛红[3] 匡秀青[3] 黄柳向[1] 程丑夫[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南九典制药有限公司,湖南长沙410031 [3]湖南中医药大学,湖南长沙410208

出　　处：《中医药导报》2014年第14期15-18,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重大新药创制重大专项(2010ZX09101-103);2013年全国名老中医药专家传承工作室建设项目:程丑夫名医传承工作室(国中医药人教发[2013]47号)

摘　　要：目的:观察降脂消斑片对鹌鹑动脉粥样硬化(AS)模型心肌及肝脏组织匀浆脂质含量的影响。方法:采用单纯高脂饲料喂养方法复制鹌鹑AS模型。分别给予降脂消斑片高、中、低剂量及阳性对照药物辛伐他汀片、脂降宁片治疗,观察对心肌及肝脏组织匀浆脂质含量的影响。结果:与模型组比较,降脂消斑片高、中剂量组具有降低肝组织、心肌组织匀浆脂质含量的作用,差异有统计学意义(P<0.01或P<0.05)。结论:降脂消斑片能降低鹌鹑AS模型的心肌及肝脏组织匀浆脂质含量。Objective： To observe the effects of Jiangzhi Xiaoban Pill（降脂消斑片, JZXBP） on myocardial and hepatic fat in quails with atherosclerosis（AS） model. Methods： Pure high cholesterol diet was applied to replicate models of AS in quails, which were respectively given high, middle and low dose of JZXBP, as well as the positive control drugs Simvastatin Tablets and Jiangzhining Tablets. The effects on myocardial and hepatic fat were observed. Results： Compared with the model group, JZXBP high and middle dose group could evidently lower the level of fat in hepatic and myocardial（P〈0.01 or P〈0.05）. Conclusion： JZXBP could evidently lower the level of myocardial and hepatic fat in quails with AS model.

关 键 词：降脂消斑片 鹌鹑 动脉粥样硬化 心肌及肝脏组织匀浆脂质含量 

分 类 号：R285.5[医药卫生—中药学]