养生保健1号方干预老年慢性疲劳综合征的临床研究  

Clinical Study of Yangsheng Baojian 1 Formula in Treatment of Chronic Fatigue Syndrome in Elderly Patients

作　　者：钱妍[1] 吴整军[1] 仝战旗[1] 陈利平[1] 段冬梅[1] 臧倩[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《中华中医药学刊》2014年第11期2573-2575,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：军队"十二五"重点项目(BWS11J031)

摘　　要：目的:评价养生保健1号方对老年慢性疲劳综合征的治疗效果。方法:选择医院80例符合慢性疲劳综合征的老年人为受试者。随机分为试验组(n=40)及安慰剂组(n=40),两组患者分别给予养生保健1号方及安慰剂干预45天。运用疲劳量表-14(Fatigue Scale 14,FS-14)评分判断患者用药前后疲劳等症状变化,同时对患者外周血T淋巴细胞亚群进行分析。结果:服药6周后,FS-14分析结果显示治疗组总有效率(35/40)87.5%,安慰剂组总有效率(5/40)12.5%,治疗组疗效优于安慰剂组(P<0.01)。治疗组NK细胞、CD3 T淋巴细胞检测较治疗前明显升高(P<0.05),与对照组差异显著(P<0.05),CD4/CD8治疗后轻度升高,但统计学无明显差异(P>0.05)。安慰剂组用药前后免疫各项指标变化不明显(P>0.05)。结论:养生保健1号方对治疗老年慢性疲劳综合征有效,对患者的免疫功能具有一定的调节作用。Objective ： To evaluate the efficacy of Yangsheng Baojian 1 Formula, a compound traditional Chinese herbal medicine for treatment of chronic fatigue syndrome （CFS） in elderly patients. Methods：The study period was 45 days. 80 cases of CFS were divided randomly into the treatment group （ n =40） and control group （ n =40）. The total score of Fatigue Scale - 14 （FS - 14） was used to evaluate the fatigue status of subjects and the change of the peripheral blood T cell subsets was measured before and after treatment. Results ：According to the score changes of FS - 14 ,the complete effectiveness rates were 87.5% in treatment group and 12.5% in control group. The efficacy of the treatment group was superior to that of the control group （ P 〈 0. 01 ）. The number of CD3 and NK increased obviously in treatment group and more than that of control group （ P 〈 O. 05 ）. No adverse effects were found in the control group. Conclusion： Yangsheng Baojianl Formula is effective for the treatment of chronic fatigue syndrome in elderly patients and can enhance the function of cell immune.

关 键 词：养生保健1号方 慢性疲劳综合征 免疫功能 老年 

分 类 号：R285.6[医药卫生—中药学]