隔药灸预防胃癌化疗相关性呕吐临床观察  

Effect of Herb-partitioned Moxibustion on Chemotherapy-Induced Nausea and Vomiting of Gastric Cancer

作　　者：阮奕[1] 张卫星[2] 王希安 顾群浩[4] 矫健鹏[5] 刘龙[1] 

机构地区：[1]第二军医大学长海医院中医系,上海200433 [2]丽水市中医院,浙江丽水323000 [3]解放军第八医院,西藏日喀则857000 [4]上海中医药大学附属岳阳中西结合医院,上海200437 [5]上海长征医院,上海200006

出　　处：《中华中医药学刊》2014年第11期2664-2666,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81102693;81102565);军队"十一五"中医药研发推广专项项目(2006171005);第二军医大学大学生创新基金项目(MS2014042;MS2014045)

摘　　要：目的:观察隔药灸对化疗相关呕吐(CINV)的临床疗效。方法:将91例胃癌患者随机分为治疗组45例和对照组46例,两组均予SOX方案化疗,治疗组化疗当天联用隔药灸,连用14 d,休息7 d,21 d为1个周期。3个周期后观察患者化疗后第1、7、14 d呕吐症状分级,化疗后伴随症状评分及疗效,化疗完成率及KPS评分、生活质量(QOL量表)。结果:化疗后第1、7、14天治疗组呕吐患者例数均显著少于对照组(P<0.05);治疗组化疗后第14天呕吐患者例数显著少于第1天呕吐患者例数(P<0.05)。化疗后14 d治疗组胃痛、乏力及饮食减少改善均明显优于对照组(P<0.05或P<0.01)。治疗组组KPS评分、QOL量表评分明显优于对照组(P<0.05)。结论:隔药灸可有效抑制CINV,在一定程度上缓解临床伴随症状,改善生活质量和体力状况。Objective ： To evaluate the efficacy of herb - partitioned moxibustion for platinum - based chemotherapy - induced nausea and vomiting （CINV）. Methods：Totally 91 CINV patients were randomized into the treatment group （45 cases） and control group （46 cases）. Both groups were given SOX chemotherapy. The patients in the treatment group were given herbpartitioned moxibustion at the same time with the chemotherapy beginning,for 14 days and following a latency of 7 days. One treatment course lasted for 21 days. The vomiting degree, vomiting times, associated symptoms, Karnofsky score （ KFS）, the European Organization for Research and Treatment of Cancer （EORTC） Quality of Life Questionnaires （QLQ） were observed after two treatment courses. Results ： Compared with the control group, the vomiting degree decreased significantly in the treatment group on the l st,Tth and 14th day of chemotherapy （P 〈 0.05 ）, and compared with the 1 st day, the vomiting degree decreased significantly on 14th day in the treatment group. Comparing with the control group, the stomach pain,fatigue and poor appetite were significantly relieved in the treatment group on the 14th day of chemotherapy （ P 〈 0.01 or P 〈 0.05 ）. The scores of KPS and EORTC QLQ in the treatment group were superior to those in the control group （ P 〈 0. 05 ）. Conclusion ： Herb - partitioned moxibustion is effective in inhibiting CINV, relieving clin- ical symptoms, increasing chemotherapydone rate and improving quality of life.

关 键 词：化疗相关呕吐 中药治疗 隔药灸 

分 类 号：R245[医药卫生—针灸推拿学]