广西耐药结核病可疑者耐药性筛查结果分析  

Retrospective analysis of the prevalence of drug resistance in the drug resistant suspects among patients with pulmonary tuberculosis in Guangxi

作　　者：黄曙海[1] 刘飞鹰[1] 徐广保 吴腾燕[1] 梁大斌[1] 黄敏莹[1] 

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028 [2]广西壮族自治区卫生和计划生育委员会,广西南宁530021

出　　处：《应用预防医学》2014年第5期272-276,共5页Applied Preventive Medicine

基　　金：广西科学研究与技术开发计划项目(桂科攻1140003A-36)

摘　　要：目的通过对广西耐药结核病可疑者筛查结果分析,了解可疑者耐药、耐多药疫情现状与特点。方法采用回顾性调查方法,对2012年1月至2014年6月期间结核病管理信息系统登记的耐药结核病可疑者筛查资料进行统计分析。结果共有657例患者有菌种鉴定和药敏试验结果,主要分布在南宁、柳州、桂林、梧州、北海、贵港和贺州等7个市。非结核分枝杆菌感染占患者总数的5.0%(33/657),而在新患者中占3.4%(12/348),在复治患者中占6.8%(21/309)。新患者总耐药率为19.6%(66/336),复治患者总耐药率为56.3%(162/288);新患者耐多药率为7.7%(26/336),复治患者耐多药率为41.3%(119/288),广泛耐多药率0.7%(2/288)。桂林市复治患者单耐利福平(RMR-TB)率高达18.8%(6/32)。结论广西结核病耐药可疑者耐药率、耐多药率高,个别市RMR-TB率、非结核分枝杆菌感染率高,应引起重视。Objective To determine the prevalence of the drug resistant tuberculosis among antibiotic resistant suspects in Guangxi. Methods A retrospective survey was conducted to collect surveillance data on TB patients who were suspicious to anti-TB drug resistance. All data was derived from National Tuberculosis Management Information System on TB patients who were suspicious to resisting anti-TB drug, from January 2012 to June 2014 in Guangxi. Results Among 657 suspects from 7 cities of Nanning, Liuzhou, Guilin, Wuzhou, Beihai, Guigang and Hezhou, 3.4 % （12/348） of the new cases and 6.8% （21/309） of the retreated cases were identified as nontuberculosis Mycobacteria （NTM） infection respectively. Drug sensitive test showed that 19.6% （66/336） of the new cases and 56.3%（162/288） of the retreated cases were any drug resistant, 7.7%（26/336） of new cases and 41.3%（119/288） of the retreated cases were MDR-TB. Furthermore,18.8%（6/32）of the retreated cases from Guilin were rifampin-monoresistant （RMR）. Conclusion It should be paid attention to high prevalence of anti-TB drug resistance especially MDR, RMR and NTM among TB patients who are suspicious to anti-TB drug resistance in Guangxi.

关 键 词：结核病 耐药 监测 可疑者 广西 

分 类 号：R714.256[医药卫生—妇产科学]