碧血胶囊对大鼠急性心肌缺血的保护作用  

Protective effects of Bixue capsule on acute myocardial infarction rats

作　　者：李娟莉[1] 陆奕宇[1] 苏式兵[1] 

机构地区：[1]上海中医药大学复杂系统研究中心,201203

出　　处：《环球中医药》2014年第11期826-829,共4页Global Traditional Chinese Medicine

基　　金：上海市教委E-研究院中医内科建设计划(E03008)

摘　　要：目的探讨碧血胶囊对大鼠急性心肌梗死的保护作用。方法采用麻醉开胸结扎冠状动脉左前降支造成急性心肌梗死模型,将60只雄性SD大鼠随机分为:假手术组、急性心肌梗死模型组、通心络组、碧血胶囊高、低剂量组、地尔硫卓组。测定用药前后大鼠模型心电图、心律失常、心梗面积以及血清肌酸激酶、乳酸脱氢酶、丙二醛、超氧化物歧化酶的变化。结果与急性心肌梗死模型组比较,碧血胶囊高剂量组能够明显减少冠脉结扎大鼠的心肌梗死面积(P<0.05)及血中丙二醛、肌酸激酶的含量(P<0.05),显著降低急性心肌缺血所致T波的高抬(P<0.01)。结论碧血胶囊能减轻大鼠心肌梗死时的心肌缺血程度及心律失常的发生率,降低心肌梗死面积及血清肌酸激酶和丙二醛的水平,对大鼠急性心肌梗死具有一定的保护作用。Objective To investigate the protective effects of Bixue capsule on acute myocardial infarction ischemia rats. Methods Acute Myocardial Infarction （ AMI） model was induced by left coro-nary artery ligation. Sixty healthy Spraugue-Dawley male rats were randomly divided into sham operated group, MI group, high and low dose Bixue capsule groups, Diltiazem groups and Tongxinluo capsule con-trol groups. The changes of T waveform, MI area and serum SOD, MDA, LDH, CK levels were measured after ligation. Results compared to MI group, high dose Bixue capsule group can reduce the increased MI area （P〈0. 05）, serum CK and MDA levels （P〈0. 05） and T waveform （P〈0. 01） caused by acute myocardial ischemia. Conclusion Pretreatment with Bixue capsule effectively improved the ischemic myo-cardial through reducing T waveform, myocardial infarction area and serum CK and MDA levels.

关 键 词：碧血胶囊 心肌梗死 心肌缺血 大鼠 

分 类 号：R256.2[医药卫生—中医内科学]