黄精水提取液对离体灌流蛙心收缩力和心率影响的研究  

作　　者：黄运[1] 吴君相[1] 陈传敏[1] 王彩冰[2] 黄彦峰[2] 

机构地区：[1]右江民族医学院临床学院,广西533000 [2]右江民族医学院基础学院,广西533000

出　　处：《当代医学》2014年第31期11-12,共2页Contemporary Medicine

摘　　要：目的观察黄精提取液对离体灌流蛙心收缩力和心率的影响。方法制备离体灌流蛙心40个,随机分为4组。正常对照组给予任氏液80μL,黄精低、中、高浓度组给予黄精提取液(0.25、0.5、1.0 g/m L)80μL,分别加入相应的离体蛙心灌流液中,观察加药前、后的蛙心收缩力和心率变化。结果黄精低、中、高浓度组给药后的心肌收缩力明显小于给药前(P<0.05)。给药后:黄精低浓度组与正常对照组的心肌收缩力比较无显著性差异;黄精中浓度组的心肌收缩力明显小于正常对照组(P<0.01),而与黄精低浓度组比较无显著性差异;黄精高浓度组的心肌收缩力明显小于正常对照组和黄精低、中浓度组(P<0.01)。结论黄精提取液能降低心肌收缩力并呈量效关系,对心率没有影响作用。Objective To observe Polygonatum extract of effect on isolated perfused frog heart contractility and heart rate.Methods Preparation the isolated perfused frog heart 40, were randomly divided into 4 groups. Normal control group received Ringer solution of 80μL. Polygonatum low, high, and concentration in the group given the Polygonatum extract （0.25, 0.5, 1.0g/mL） 80μL, were respectively added to the corresponding isolated frog heart perfusate, then observed the change of frog heart contractility and heart rate dosing before and after.Results Polygonatum in low, high, and concentration group of myocardial contractility after given drugs was significantly lower than that before drugs （P〈0.05）. Administration： there is no significant difference between the myocardial contractilityof Polygonatum low concentration group and normal control group; Myocardial contractility Polygonatum concentration group was obviously less than the normal control group （P〈0.01）, and Polygonatum concentration group showed no significant difference with Polygonatum low group; Myocardial contractility force of Polygonatum in high concentration group was significantly less than the normal control group and the low concentration of polygonatum group （P〈0.01）.Conclusion Polygonatum extract can decrease the myocardial contractility and showed a dose effect relationship and no effect on heart rate.

关 键 词：黄精 心肌收缩力 心率 离体蛙心灌流 

分 类 号：R285.5[医药卫生—中药学]