PCT、LTB_4检测在慢性阻塞性肺疾病急性发作期中的诊断意义  

Clinical significance of procalcitonin and leuotriene B_4 in acute exacerbation of chronic obstructive pulmonary disease

作　　者：谢飞[1] 李晓强[1] 

机构地区：[1]湖北医药学院附属太和医院检验科,湖北十堰442000

出　　处：《现代预防医学》2014年第22期4194-4196,共3页Modern Preventive Medicine

摘　　要：目的探讨血清降钙素原(Procalcitonin,PCT)及白三烯B4(Leukotriene B4,LTB4)表达水平的改变,探讨其在慢性阻塞性肺疾病急性加重期(Acute Exacerbations of Chronic Obstructive Pulmonary Disease,AECOPD)中的临床意义。方法选取42例COPD急性期患者为观察组,同时选取稳定期患者36例作为对照组,监测血清中PCT和LTB4的水平,并动态检测各指标在AECOPD患者治疗前后的变化。结果 (1)COPD患者急性发作期患者血清中PCT浓度为(1.30±0.22)μg/L,COPD稳定期患者血清中的浓度为(0.18±0.05)μg/L,差异有统计学意义(P<0.05);(2)COPD患者急性发作期患者血清中LTB4浓度为(11.30±2.0)μg/L,COPD稳定期患者血清中的浓度为(2.0±0.36)μg/L,差异有统计学意义(P<0.05);(3)PCT和LTB4的浓度在治疗后较治疗前出现了下降。PCT的下降明显,其差异有统计学意义(P<0.05)。结论 PCT和LTB4是COPD急性发作期较好的监控指标,并且PCT比LTB4能更早发现COPD急性期的缓解。Objective The aim of this study was to investigate the clinical application value of the serum procalcitonin （PCT） and leukotriene B4 （LTB4） for the patients with acute exacerbations of chronic obstructive pulmonary disease （AECOPD）. Methods Forty-two cases of AECOPD patients were randomly selected and 36 cases of COPD stable period patients were used as the control group. The concentrations of PCT and LTB4 in serum were examined. Various inflammatory indicators were dynamically observed in the patients before and after the treatment. Results （1） The serum PCT level of the AECOPD patients was （1.30 ± 0.22） g/L, while the serum PCT level of the stable COPD patients was （0.18 ± 0.05） g/L, and the difference was statistically significant （P〈0.05）. （2） The serum LTB4 level of the AECOPD patients was （11.30 ± 2.0） g/L, while the serum PCT level of the stable COPD patients was （2.0 ± 0.36） g/L, and the difference was statistically significant （P〈0.05）. （3） After the treatment, the serum PCT and LTB4 levels were decreased in the AECOPD patients, while the decrease in serum PCT level was statistically significant （P〈0.05）. Conclusion The combined examination of the PCT and LTB4 is helpful in diagnosing AECOPD patients, and the level of PCT is better than LTB4 in detecting early remission of AECOPD.

关 键 词：降钙素原 白三烯B4 慢性阻塞性肺疾病 急性发作 

分 类 号：R446[医药卫生—诊断学]