胎盘多肽对门脉高压症术后肝脏和免疫功能分析  

The effect of placenta polypeptide on liver and immune function of patients of hepatic cirrhosis portal hypertension after surgery

作　　者：许永庆[1] 卜献民[1] 戴朝六[1] 徐锋[1] 赵闯[1] 赵亮[1] 

机构地区：[1]中国医科大学附属盛京医院肝胆脾外科,辽宁沈阳110004

出　　处：《现代预防医学》2014年第22期4197-4199,4207,共4页Modern Preventive Medicine

摘　　要：目的观察胎盘多肽对肝硬化门脉高压症患者断流术后肝脏和免疫功能的影响,并评估其临床疗效。方法将60例患有门脉高压症接受脾切除、贲门周围血管离断术的患者随机分为2组,Ⅰ组(n=30)为胎盘多肽治疗组,Ⅱ组(n=30)为对照组,2组分别于术前1 d,术后1、3、7 d抽取静脉血,检测T细胞亚群(CD4、CD8、CD4/CD8)、IL-6、ALT、AST,并观察感染发生率及出院时间的变化。结果 (1)Ⅰ、Ⅱ组CD4、CD8、CD4/CD8术后均较术前下降,d 1下降明显,d 3、d 7逐渐升高,术后Ⅰ组高于Ⅱ组,但差异无统计学意义(P>0.05);(2)Ⅰ、Ⅱ组IL-6术后较术前升高,d 1升高明显,d 3、d 7逐渐下降,Ⅰ组下降较Ⅱ组快,但差异无统计学意义(P>0.05)。(3)Ⅰ、Ⅱ组谷丙转氨酶(ALT)、谷草转氨酶(AST)均先升高后下降,Ⅰ组低于Ⅱ组,d 3、d 7差异有统计学意义(P<0.05)。(4)Ⅰ组较Ⅱ组感染发生率及住院时间无统计学差异(P>0.05)。结论门脉高压症术后应用胎盘多肽治疗,可在一定程度上促进患者免疫功能的恢复,起到保护肝脏功能的作用。Objective This study was to investigate the effect of placenta polypeptide on the liver and immune function of hepatic cirrhosis portal hypertension patients after the disconnection surgery and to evaluate the clinical efficacy. Methods 60 patients having received spleen removal and peficardial devascularization were randomly divided into two groups, group I （n=30） was the placenta polypeptide group, group Ⅱ（n=30） was the control group. Venous blood samples were drawn on the day before surgery, and one, two and three days after surgery, respectively. The levels of CD4, CD8, CD4/CD8） , IL-6, ALT, AST were determined, the rate of infection and the discharge time of patients were recorded. Results Compared to that before surgery, the levels of CD4, CD8, CD4/CD8 of group Ⅰ, Ⅱ were lower after surgery, with the most significant on the first day. The levels then gradually increased 3 and 7 days after surgery. No significant difference was observed between the two groups. The IL-6 level of group I and Ⅱwas higher after surgery, with the most significant increase on the first day, then decreased gradually after 3 and 7 days. There was no significant difference between the two groups. Similarly, after surgery the levels of ALT and AST increased at first and decreased. The ALT and AST levels of group I were lower than group II, and the difference was significantly different （P〈0.05）. No significant difference in the infection rate and hospital discharge time was observed between two groups. Conclusion Placenta polypeptides have significant effect on the liver and immune function of hepatic cirrhosis portal hypertension patients after disconnection surgery. It can improve the immune function and protect the liver of patients.

关 键 词：胎盘多肽 门脉高压症 CD4 CD8 IL-6 ALT AST 

分 类 号：R446.63[医药卫生—诊断学]