血清LDL-C、HCY和hs-CRP联合检测在动脉粥样硬化诊断中的价值  

Value of combined detection of serum LDL-C,HCY and hs-CRP in the diagnosis of atherosclerosis

作　　者：焦晓宁[1] 韩玉冰[1] 

机构地区：[1]河南省濮阳市中医院检验科,河南濮阳457001

出　　处：《中国当代医药》2014年第31期96-97,99,共3页China Modern Medicine

摘　　要：目的探讨联合检测血清低密度脂蛋白胆固醇(LDL-C)、同型半光氨酸(HCY)和超敏C反应蛋白(hs-CRP)在动脉粥样硬化诊断中的价值。方法选取95例动脉粥样硬化患者(观察组)和95例无动脉粥样硬化患者(对照组)作为研究对象,所有患者均经冠状动脉造影证实。测定两组的血清LDL-C、HCY以及hs-CRP浓度。结果动脉粥样硬化患者血清LDL、HCY以及hs-CRP水平较对照组明显升高,其阳性率分别为72.63%、76.84%、84.10%,差异有统计学意义(P<0.05)。LDL-C、HCY与hs-CRP联合诊断动脉粥样硬化的阳性率为96.84%,明显高于单独检测。结论无论是LDL、HCY还是hs-CRP,在对动脉粥样硬化进行早期诊断、评估时都是独立的指标,如联合检测,意义更大。Objective To explore the value of combined detection of serum LDL-C,HCY and hs-CRP in the diagnosis of atherosclerosis. Methods 95 cases with atherosclerosis （the observation group） and 95 cases with no atherosclerosis （the control group） were selected as research object,all patients were confirmed by coronary angiography.The serum LDL,HCY and hs-CRP concentrations of all the patients were detected. Results The level of serum LD,HCY and hs-CRP with atherosclerosis was significantly higher than that of the control group,and the positive rates were 72.63%,76.84%, 84.10% respectively,with statistical difference （P〈0.05）.The positive rate of combined detection of serum LDL-C,HCY and hs-CRP in the diagnosis of atherosclerosis was 96.84%,which was significantly higher than that of simple detection. Conclusion LDL,HCY and hs-CRP are independent indicators for the early diagnosis and evaluation of atherosclerosis. Combined detection of the three indicators has greater significance.

关 键 词：动脉粥样硬化 低密度脂蛋白胆固醇(LDL-C) 血清同型半光氨酸(HCY) 超敏C反应蛋白(hs-CRP) 

分 类 号：R446.112[医药卫生—诊断学]