细胞周期调控蛋白Cdkn2a对于CD8^+T细胞中IL-10表达调控机制的初步研究  

The Preliminary Study of Regulation Mechanism of Cell Cycle Regulatory Protein-Cdkn2a on IL-10 Expression in CD8^+T Cells

作　　者：赵惠媛[1] 祁晓飞 孙月红[1] 袁一方[1] 赵立青[1] 

机构地区：[1]南开大学生命科学学院,天津300071

出　　处：《南开大学学报（自然科学版）》2014年第5期42-47,共6页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：国家自然科学基金(31170858;30007101)

摘　　要：IL-10是一种典型的抑制性炎症因子,在机体免疫反应中发挥着重要的作用,探明该因子的表达调控机制对于阐释免疫应答在炎症反应、肿瘤发生发展等过程中的作用机制均具有重要意义.在前期工作的基础上,利用IL-10转基因报告小鼠10BiT,对细胞周期调控蛋白Cdkn2a在IL-10分泌型CD8+T细胞中调控IL-10表达的机制进行了初步探讨.结果显示,Cdkn2a对于CD8+T细胞中IL-10的表达调控与细胞分裂无关,而是可能作用于IL-4信号通路的下游来发挥作用.该工作为深入探讨Cdkn2a对IL-10的表达调控机制奠定了初步的基础.IL-10 is an important anti-inflammatory cytokine which plays a critical role in immune responses.It is of great significance to explore the regulation mechanism of IL-10 expression for the interpretation of the mechanisms of the immune response in the process of inflammatory response and tumor genesis and development.On the basis of previous work,using IL-10 transgenic reporter mice 10 BiT,the fundamental discussion about the cell cycle regulatory protein-Cdkn2 a,for the regulation mechanism of IL-10 expression in IL-10-secreting CD8＋T cells was discussed.The results demonstrated that Cdkn2 apossibly affected IL-10 expression in CD8＋T cells in the downstream of IL-4signal pathway,but was irrelevant to cell division.Our results provided the foundation for further research of Cdkn2 ain the regulation of IL-10 expression.

关 键 词：CDKN2A IL-10 细胞分裂 IL-4 

分 类 号：Q813[生物学—生物工程]