肾淀粉样变性病4例临床及病理特点分析  

Analysis of clinical characteristics of 4 patients with renal amyloidosis and literature review

作　　者：鲁文娟 李永贤 

机构地区：[1]莒南县人民医院肾内科,山东莒南276600

出　　处：《泰山医学院学报》2014年第10期1040-1042,共3页Journal of Taishan Medical College

摘　　要：目的通过对4例肾淀粉样变性患者的临床及病理分析,提高对该病认识。方法回顾性分析4例经肾活检确诊为淀粉样变性病患者的临床资料及病理特点。结果 4名患者年龄≥58岁,均出现肾病综合征,2例伴多系统受累;刚果红染色阳性,4例均为AL型,其中3例免疫荧光λ链阳性。结论伴多系统损害或激素治疗欠佳的中老年肾病综合征患者,要考虑到肾淀粉样变性病的可能;肾活检应常规行刚果红染色及电镜检查。Objective：To describe the clinical and pathological characteristics of renal amyloidosis,to improve the diag-nosis level. Methods：The clinical and pathological data of 4 patients with renal amyloidosis were retrospect - tively ana-lyzed,who were diagnosed by renal biopsy. Results：4 patients were over 58 years old,and all presented nephrotic syndrome with severe hypoalbuminemia,2 case had more than two systems involvement. Congo red staining were positive,all patients were AL type,light chain λ were detected in 3 patients. Conclusion：Amyloidosis should be considered in elderly patients with nephrotic syndrome,who had multisystem damage or steroid resistance. Congo red stain and transmission electron mi-croscope should be included in renal biopsy.

关 键 词：肾淀粉样变 肾病综合征 肾活检 

分 类 号：R597.2[医药卫生—内科学]