橙皮苷在碱性溶液中的稳定性研究  

Studies on Stability of Hesperidin in Alkaline Solution

作　　者：胡玉梅[1] 孟兆青[1,2] 张珊[1] 程宁波[1] 丁岗[1] 王振中[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司,连云港222001 [2]中国药科大学中药学院,南京210009

出　　处：《世界科学技术-中医药现代化》2014年第10期2270-2273,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家国际科技合作计划(2013DFA31090):中药治疗胃肠道炎性疾病药效评价体系建立;负责人:王振中

摘　　要：目的:研究橙皮苷在碱性溶液中的稳定性,为其提取、纯化工艺的质量控制以及制剂产品的开发提供实验依据。方法:采用RP-HPLC法测定不同温度、p H、加热时间下橙皮苷的含量变化。结果:加热条件下橙皮苷碱性溶液发生了降解,含量随加热温度的升高和加热时间的延长,呈不断下降趋势;弱碱条件下较稳定。结论:为保证溶液中橙皮苷的稳定,在生产过程中应使溶液处于低温(50℃以下)及弱碱条件下,并尽量减少溶液的受热时间。This article was aimed to study the stability of hesperidin in alkaline solution, in order to provide experiment evidences for quality control of extraction and purification as well as formulation development. RP-HPLC was applied to determinate content changes of hesperidin in alkaline solution by changing the temperature, pH and heating time. The results showed that hesperidin was degraded in alkaline solution by heating. The content of hesperidin decreased along with the increasing of heating temperature and heating time. The hesperidin appeared to be more stable in a weak base. It was concluded that for the purpose of ensuring of the stability of hesperidin in alkaline solution, it should be kept at low temperature（below 50℃）, weak base conditions and shorten the heating time during the preparation process.

关 键 词：橙皮苷 稳定性 高效液相色谱法 降解产物 

分 类 号：R284[医药卫生—中药学]