乙二胺四乙酸铁钠强化调味品防治贫血效果的Meta分析  

Meta analysis of condiments fortified with sodium iron ethylenediaminetetraacetate on the prevention and treatment of anemia

作　　者：郭慧[1] 李文芳[1] 梅勇[1] 曾婧[1] 

机构地区：[1]武汉科技大学公共卫生学院,武汉430065

出　　处：《卫生研究》2014年第6期998-1003,共6页Journal of Hygiene Research

基　　金：湖北省教育厅人文社科基金指导性项目(No.14G099)

摘　　要：目的评价乙二胺四乙酸铁钠（NaFe-EDTA）强化调味品防治贫血的效果。方法计算机检索TheCochraneLibrary、MEDLINE、EMbase、WHOLIS、EBSCO、HighWirePress、PubMed、CNKI、WanFangData、VIP和CBM，采用Cochrane系统评价的方法，运用RevMan5．2．6软件进行Meta分析。结果8项随机对照试验纳入研究，与对照组相比，NaFe-EDTA强化调味品干预能有效提高血红蛋白浓度（WMD=3．2g／L，95％CI2．9～3．5，P〈0．001）。分层分析结果发现学龄儿童少年食用NaFe—EDTA强化调味品对降低缺铁性贫血患病率的效果最明显（OR=0．4，95％C，0．2～0．5），其次是育龄妇女（OR=0．5，95％C10．4～0．6），而对学龄前儿童作用不明显（OR=0．7，95％C10．4～1．0）。结论NaFe-EDTA强化调味品干预可提高血红蛋白水平，对缺铁性贫血起到保护作用，但是对学龄前儿童贫血的防治效果评价，仍需要更充足的证据。Objective To evaluate the effect of condiments fortified with sodium iron ethylenediaminetetraacetate （NaFe-EDTA） on the prevention and treatment of anemia. Methods The randomized controlled trials about condiments fortified with NaFe-EDTA on the prevention and treatment of anemia were collected in such databases as The Cochrane Library, MEDLINE, EMbase, WHOLIS, EBSCO, HighWire Press, PubMed, CNKI, WanFang Data, VIP and CBM. Data were evaluated with the method of Cochrane systematic review by using RevMan 5.2.6. Results Seven randomized controlled trials were included. NaFe-EDTA fortification group increased hemoglobin level by 3.2 g/L （ weighted mean difference, 95% CI 2.9 - 3.5, P 〈 0. 001 ） compared with control group. Subgroup analysis found that the clearest results of NaFe-EDTA fortification to prevent anemia is in school children （ OR = 0.4, 95% CI 0.2 - 0.5 ） , the posterior of that is in child-bearing period women （ OR = 0.5, 95% CI 0.4 - 0.6） , while which has effect in preschool children but quite part of them were still unable to achieve the normal hemoglobin standard （ OR = 0.7, 95% CI 0.4 - 1.0）. Conclusion Condiments fortified with NaFe-EDTA is able to improve hemoglobin level and prevent anemia. However, more evidences should be collected to evaluate the prevention effect in preschool children.

关 键 词：乙二胺四乙酸铁钠 缺铁性贫血 铁强化 META分析 

分 类 号：R556.3[医药卫生—血液循环系统疾病] TS264.2[医药卫生—内科学]