MicroRNA介导中药活性成分抗肿瘤机制的研究进展  

Progression in anti-tumor effects of active ingredients of traditional Chinese medicine mediated by microRNA

作　　者：贵志芳 任军[1] 许健[1] 

机构地区：[1]浙江中医药大学医学技术学院,杭州310053

出　　处：《生命科学》2014年第11期1215-1221,共7页Chinese Bulletin of Life Sciences

基　　金：浙江省自然科学基金项目(LY14H160037;LY12H16007);浙江省科技厅钱江人才项目(2013R-10072)

摘　　要：MicroRNA(miRNA)作为一类新发现的非编码RNA,其异常表达在肿瘤的病理过程中扮演着重要角色,起着类似癌基因和抑癌基因的双重作用。目前中药活性成分抗肿瘤已成为关注的热点,但其影响miRNA的报道却较少。就近几年有关中药活性成分、miRNA及肿瘤间关系的研究进行了综述,为今后中药活性成分抗肿瘤的机制研究提供新思路。As a new type of non-coding RNA, microRNA plays an important dual role in the progression of tumor,by functioning as a tumor suppress gene or anrogen. Currently, the active ingredients of traditional Chinese medicine already have become the popular topic of anti-tumor research, but its influence on microRNA was lessreported. This article summarized recent researches about the relationship among miRNA, tumor and active ingredients of the traditional Chinese medicine, discussed the anti-tumor mechanisms of the active ingredients of traditional Chinese medicine mediated by microRNA, which can provide a new way for the further research of theanti-tumor mechanisms of the active ingredients of traditional Chinese medicine.

关 键 词：MIRNA 肿瘤 中药活性成分 

分 类 号：Q522[生物学—生物化学] R2-031[医药卫生—中西医结合]