四制香附对大鼠离体子宫平滑肌收缩的影响及作用机制研究  

Effect of Jianchangbang Processing Methods for Rhizoma Decotion Contractile Activity of Uterine Smooth Muscle Stripes of Non-pregnant Rats in Vitro

作　　者：郭慧玲[1] 许茜茜[1] 胡志方[2] 胡律江[1] 赵晓娟[1] 闫柏屹[1] 

机构地区：[1]江西中医药大学,江西南昌330004 [2]江西中医药高等专科学校,江西抚州344000

出　　处：《江西中医药大学学报》2014年第5期76-78,共3页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省卫生厅中医药科研计划项目(2013Z008;2013A190);江西中医药大学校级课题(2012ZX3006);江西省教育厅科技落地计划项目(KJLD14057)

摘　　要：目的:探讨建昌帮四制香附及其石油醚部位对未孕大鼠离体子宫平滑肌收缩作用的影响及其机制。方法:采用雌性未孕大鼠,灌胃己烯雌酚致敏,制备离体子宫标本,通过powerlab生物信号采集系统考察生香附、四制香附及其石油醚部位各提取液及α-香附酮对由缩宫素引起的大鼠离体子宫平滑肌收缩的抑制作用,并通过加入受体拮抗剂初步探讨其作用机制。结果:各样品对未孕大鼠离体子宫平滑肌收缩的抑制作用强弱依次为:四制香附石油醚部位﹥四制香附﹥α-香附酮﹥生香附,且α-香附酮、四制香附及其石油醚部位呈现剂量依赖性地抑制子宫平滑肌的收缩作用。结论:四制香附及其石油醚部位抑制子宫平滑肌收缩的作用优于α-香附酮和生香附。Objective ： To study the effects of Jianchangbang processing methods for Rhizoma and petroleum ether part on contractile ac- tivity of uterine smooth muscle strips of non - pregnant rats. Methods：Selected non - pregnant rats to record the effects of different ex- tractions of rhizoma cyperi, rhizoma cyperi processed by jianchangbang method and o~ - Cyperone on contractive activity of uterine smooth muscle strips of non - pregnant rats with Powerlab System. Two antagonists were used to study their mechanisms respectively. Results ： Each sample could weaken uterine contractile activity of non - pregnant rats in strength sequence ： petroleum ether portion of processing rhizoma cyperi 〉 rhizoma cyperi processed by jianchangbang method 〉 α - Cyperone 〉 nutgrass galingale rhizome . Con clusion：Rhizoma eypcri processed by jianchangbang method and petroleum ether portion can inhibit uterine smooth muscle more effec- tively compared to α - Cyperone and rhizoma cyperi .

关 键 词：香附 建昌帮四制香附 离体子宫平滑肌 大鼠 

分 类 号：R285.5[医药卫生—中药学]