缬沙坦对高血压并阵发性心房颤动患者炎症因子的干预作用  

Effect of Valsartan on Inflammatory Cytokines in Patients With Hypertension Combining Paroxysmal Atrial Fibrillation

作　　者：李静[1] 张燕群[1] 黄婼[1] 

机构地区：[1]莱芜市人民医院干部保健科,山东省271100

出　　处：《中国循环杂志》2014年第11期888-890,共3页Chinese Circulation Journal

摘　　要：目的 :探讨缬沙坦对高血压并阵发性心房颤动(PAF)患者体内炎症因子的干预作用。方法:选择高血压合并PAF已转复窦性心律患者60例,随机分为缬沙坦组30例和对照组30例,对照组口服非洛地平缓释片,缬沙坦组口服缬沙坦胶囊,疗程为6个月。另选取同期健康体检正常者3O例为正常组。于治疗前后分别检测高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、左心房舒张末期内径(LADd)及心房颤动复律后窦性心律的维持率。结果:对照组、缬沙坦组两组患者hs-CRP、IL-6、LADd均显著高于正常组(P均<0.01),治疗6个月后,两组患者hs-CRP、IL-6、LADd均较治疗前显著下降(P<0.O1),但缬沙坦组更显著(P均<0.01)。缬沙坦组窦性心律维持率显著高于对照组(P<0.05)。结论:缬沙坦可能通过抑制炎症反应改善心房结构重构,从而更好的维持高血压合并PAF患者复律后的窦性心律,其抗炎作用可能独立于其降压作用。Objective： To explore the effect of valsartan on inflammatory cytokines in patients with hypertension combining paroxysmal atrial fibrillation （PAF）. Methods： A total of 60 patients with hypertension combining PAF converted to sinus rhythm were studied and the patients were divided into 2 groups. Control group, the patients received felodipine and Valsartan group, n=30 in each group, all patients were treated for 6 months. In addition, there was a Normal group including 30 healthy subjects. The levels of high sensitive C-reactive protein （hs-CRP）, interleukin-6 （IL-6） and left atrial diastolic diameter （LADd）, the sinus rhythm maintenance rate were examined and compared before and after treatment among different groups. Results： Compared with Normal group, the levels of hs-CRP, IL-6 and LADd were obviously higher in patients at both Control group and Valsartan group, all P〈0.01. With 6 months of treatment, the levels of hs-CRP, IL-6 and LADd were decreased in both groups of patients than they were before, all P〈0.01; compared with Control group, such effects were more obvious in Valsartan group, all P〈0.01. The sinus rhythm maintenance rate in Valsartan group was significantly higher than that in Control group, P〈0.05. Conclusion： Valsartan may inhibit inflammatory response and improve atrial structure remodeling, therefore better maintain the converted sinus rhythm in patients with hypertension combining PAE The anti-inflammatory effect of valsartan might be independent from its anti-hypertension effect.

关 键 词：缬沙坦 阵发性心房颤动 高敏C反应蛋白 白细胞介素-6 

分 类 号：R54[医药卫生—心血管疾病]