铅毒性拮抗剂的研究进展  

Advances on Lead Antagonist

作　　者：刘洪娟[1] 吕翠[1] 刘晓丽[1] 张文生[1] 

机构地区：[1]北京师范大学中药资源保护与利用北京市重点实验室,北京100875

出　　处：《环境与职业医学》2014年第11期882-886,共5页Journal of Environmental and Occupational Medicine

摘　　要：铅为重要的有毒重金属污染物之一,可对心血管系统、神经系统、泌尿系统、生殖系统、免疫系统等造成损伤。铅造成损伤的机制主要有影响钙离子(Ca2+)通道,导致细胞凋亡,造成氧化损伤等多方面,针对铅损伤机制筛选合适的铅拮抗剂是目前的研究热点。本文为了解相关拮抗机制,总结了近年来的相关报道,发现仅有小部分天然化合物具有直接促排铅效果,而大部分天然化合物是通过维持机体的氧化/抗氧化平衡及抗炎症损伤作用来拮抗铅毒性,因此我们认为需要从具有抗炎、抗氧化功效的天然成分中筛选合适的铅及其他相似重金属拮抗剂。Lead is one significant toxic heavy metal pollutant, which can damage cardiovascular system, nervous system, urinary system, reproductive system, immune system, and so on.The studied mechanisms of lead damage include affecting Ca2＋ ion channels to cause apoptosis, oxidative damage, etc.Screening for damage mechanism-based antagonist of lead is a current research hot spot.This paper summarized relevant reports of lead antagonists and found that only a small part of natural compounds can directly promote lead removing, while most natural compounds antagonize through maintaining oxidation/antioxidation balance and anti-inflammatory effect.Therefore, antagonist for lead and other heavy metals with similar characteristics can be identified from natural compounds with anti-inflammatory and anti-oxidant effects.

关 键 词：铅损伤 损伤机制 拮抗剂 促排铅 营养干预 

分 类 号：R18[医药卫生—流行病学]