粉尘螨滴剂治疗儿童变应性鼻炎的疗效及安全性  

Eficacy and safety of the sublingual immunotherapy with standardized dermatophagoides farinae drops in children with allergic rhinitis

作　　者：李勇[1] 阮桂英[2] 储洪娟[1] 江波[1] 陶宝鸿[1] 

机构地区：[1]浙江台州学院附属市立医院耳鼻咽喉科,浙江台州318000 [2]浙江台州学院附属市立医院儿内科,浙江台州318000

出　　处：《中国临床药理学杂志》2014年第11期991-993,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江台州市科技计划基金资助项目(1301KY32)

摘　　要：目的评价舌下含服标准化粉尘螨滴剂治疗儿童变应性鼻炎2年疗效及其安全性。方法螨过敏变应性鼻炎儿童240例随机分为观察组和对照组,各120例,对照组氯雷他定或/和康酸莫米松药物治疗,观察组加用舌下含服粉尘螨滴剂,疗程2年,评价治疗前后症状评分和药物评分及安全性。结果 2年后,观察组患儿症状评分和药物评分为(3.46±0.85),(0.28±0.43)分,较治疗前的(10.76±1.08),(1.28±0.68)分均明显减少(P均<0.05),较对照组治疗后的(9.76±1.14),(1.09±0.35)分均明显减少(P均<0.05)。观察组随访期间出现皮疹、鼻咽痒等11例,对照组出现鼻腔出血,乏力、嗜睡等10例,均未出现过敏性休克等严重全身不良反应。结论舌下含服标准化尘螨滴剂治疗尘螨引起的儿童变应性鼻炎有效,并有较好的安全性。Objective To evaluate the efficacy and safety of sublingual immunotherapy with dermatophagoides farinae standardized extrace for the treatment in children with allergic rhinitis for 2 years.Methods Two hundred and forty children with allergic rhinitis to dermatophagoides ptero-nyssinus（ Der P） were randomly allocated to receive either specific immu-notherapy（n=120）or medical treatment（n=120）.Symptom and medica-tion scores were assessed to evaluate the clinical efficacy and safety in the baseline and after two year treatment.Results Immunotherapy reduced the symptom [the scores reduced from （10.76 ±1.08） to （3.46 ±0.85）] and medication score [the scores reduced from （1.28 ±0.68） to （0.28 ± 0.43）] in children with allergic rhinitis significantly （ P 〈0.05）, and compared with the control group [ （ 9.76 ±1.14 ） and （ 1.09 ±0.35 ） ] , there was a statistical difference （P〈0.05）.Eleven local adverse reactions including allergic rash and nasopharyngeal itching occurred observation group, and ten cases of nasal bleeding, fatigue and drowsiness were found in control group, while no fatal systemic reaction occurred in both groups.Conclusion Dermatophagoides farinae standardized extrace for the treat-ment of allergic rhintis is efficacious to treat children sensitive to Der P, al-lergen individualization of dosage is recommended to improve tolerance and security.

关 键 词：鼻炎 变应性 免疫治疗 粉尘螨 疗效评价 

分 类 号：R765.21[医药卫生—耳鼻咽喉科] R987[医药卫生—临床医学]