B淋巴细胞的分化发育与自身免疫性疾病  

Development and differentiation of B cells and autoimmune diseases

作　　者：唐雪梅[1] 

机构地区：[1]重庆医科大学附属儿童医院肾脏免疫科,400014

出　　处：《中华实用儿科临床杂志》2014年第21期1611-1613,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：B淋巴细胞起源于骨髓中的造血干细胞，骨髓（禽类为法氏囊）是B淋巴细胞发育和成熟的场所。B淋巴细胞在骨髓内的发育，经历了祖B淋巴细胞、前B淋巴细胞、未成熟B淋巴细胞及成熟B淋巴细胞几个阶段。B淋巴细胞的分化过程可分为抗原非依赖期和抗原依赖期。在B淋巴细胞亚群中，CD5^＋B1细胞和分泌IL—10的B调节细胞（BIO细胞）与自身免疫性疾病的发生发展可能相关，前者可能促进炎性反应发生，后者可能有下调和抑制自身免疫性炎症的作用。Of B cells derived from bone marrow hematopoietic stem cells, bone marrow （ poultry as the bursa of fabricius） is a place of B cells development and mature. The growth of B cells can experience from progenitor cell B, pre-B cells,immature B cells and mature B cells stages in the bone marrow. The differentiation process of B cells can be divided into antigen independ stage and antigen depend stage. CD5^ ＋ B1 ceils and B10 cells of B cell subsets probably associated with autoimmune disease ,B1 ceils may play roles of promotion in inflammatory reaction, and B10 cells may suppress autoimmune inflammation.

关 键 词：B淋巴细胞 CD5^+B细胞 B调节细胞 B10细胞 自身免疫性疾病 

分 类 号：R725.9[医药卫生—儿科]