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机构地区:[1]天津市第四中心医院麻醉科,300140 [2]天津医科大学总医院麻醉科
出 处:《中华麻醉学杂志》2014年第10期1165-1167,共3页Chinese Journal of Anesthesiology
摘 要:目的 评价右美托咪定对患者压力感受性反射的影响.方法 择期全麻下行甲状腺部分切除术或鼻息肉切除术患者45例,性别不限,年龄20 ~ 60岁,BMI 18~ 24 kg/m2,ASA分级Ⅰ或Ⅱ级,采用随机数字表法,将其分为3组(n=15):正常对照组(C组)、低剂量右美托咪定组(LD组)和中等剂量右美托咪定组(MD组).LD组静脉注射右美托咪定0.5 μg/kg,随后以0.2 μg·kg^-1·h^-1速率持续输注;MD组静脉注射右美托咪定1.0 μg/kg,随后以0.5 μg·kg^-1 ·h^-1速率持续输注.右美托咪定输注30 min时采用改良牛津药理学方法测定压力感受性反射敏感性.结果 3组间压力感受性反射敏感性比较差异无统计学意义(P>0.05).结论 右美托咪定对患者压力感受性反射无明显影响.Objective To evaluate the effect of dexmedetomidine on baroreflex in the patients.Methods Forty-five ASA physical status Ⅰ or Ⅱ patients,aged 20-60 yr,with body mass index 18-24 kg/m2,scheduled for elective partial thyroidectomy or nasal polypectomy under general anesthesia,were randomly divided into 3 groups (n =15 each) using a random number table:control group (group C),low-dose dexmedetomidine group (group LD) and medium-dose dexmedetomidine group (group MD).Dexmedetomidine 0.5 μg/kg was injected intravenously followed by infusion at 0.2 μg· kg^-1 · h^-1 in group LD.Dexmedetomidine 1.0 μg/kg was injected intravenously followed by infusion at 0.5 μg· kg^-1 · h^-1 in group MD.After 30 min of dexmedetomidine infusion,a modified Oxford pharmacologic technique was used for evaluating baroreflex sensitivity.Results There was no significant difference in baroreflex sensitivity between the three groups.Conclusion Dexemedtomidine exerts no effect on baroreflex in the patients. Keywords:Dexemedetomidine; Baroreflex
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